2O21

Equipe 01 « Immunomodulation of the tumor microenvironment and immunotherapy of thoracic cancers »

Briolay T., Petithomme T., Fouet M., Nguyen-Pham N., Blanquart C., Boisgerault N.,  Delivery of cancer therapies by synthetic and bio-inspired nanovectors. Molecular Cancer., 2021, vol 20, n°1, 55 p. Réf. HAL: inserm-03187595

Bureau M., Chatellier T., Perennec T., Goronflot T., Greilsamer C., Chene A.L., Affi R., Frampas E., Bennouna J., Pons-Tostivint E.,  Baseline tumour size is an independent prognostic factor for overall survival in PD-L1 ≥ 50% non-small cell lung cancer patients treated with first-line pembrolizumab. Cancer Immunology, Immunotherapy., 2021, Online ahead of print. Réf. HAL: inserm-03540431

Carbone D., Ciuleanu T., Cobo M., Schenker M., Zurawski B., Menezes J., Richardet E., Bennouna J., Felip E., Juan-Vidal O., Alexandru A., Sakai H., De La Mora Jimenez E., Paz-Ares L., Reck M., John T., Hu N., Zhang X., Tran P., Grootendorst D., Lu S.,  First-line Nivolumab + Ipilimumab + Chemo in Patients With Advanced NSCLC and Brain Metastases: Results From CheckMate 9LA. Journal of Thoracic Oncology., 2021, vol 16, n°10, S862. Réf. HAL: inserm-03540850

Chevallier P., Saiagh S., Dehame V., Guillaume T., Peterlin P., Bercegeay S., Le Bris Y., Bossard C., Gauvrit I., Dreno B., Juge-Morineau N., Béné M. C, Gregoire M.,  A phase I/II feasibility vaccine study by autologous leukemic apoptotic corpse-pulsed dendritic cells for elderly AML patients. Human Vaccines & Immunotherapeutics., 2021, Online ahead of print. Réf. HAL: inserm-03335625

Declercq M., Treps L., Bousfia S., Carmeliet P., Witters P.,  Endothelial CFTR dysfunction and its involvement in the pathogenesis of pulmonary arterial hypertension. European Respiratory Journal., 2021, vol 58, n°2, 2101645 p. Réf. HAL: inserm-03349937

Grard M., Chatelain C., Delaunay T., Pons-Tostivint E., Bennouna J., Fonteneau J.F.,  Homozygous Co-Deletion of Type I Interferons and CDKN2A Genes in Thoracic Cancers: Potential Consequences for Therapy. Frontiers in Oncology., 2021, vol 11, 695770 p. Réf. HAL: inserm-03349933

Jin Z., Shen J., Wang C., Chen D., Zhang B., Zhang J., Ajani J. A, Bennouna J., Chao J., Yoon H. H, Zhu H., Ruan Y., Zhu C., Xu A.,  Narrative review of pembrolizumab for the treatment of esophageal cancer: evidence and outlook. Annals of translational medicine., 2021, vol 9, n°14, 1189 – 1189 p. Réf. HAL: inserm-03349940

Lavy M., Gauttier V., Poirier N., Barillé-Nion S. C, Blanquart C.,  Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities. Frontiers in Immunology., 2021, vol 12, 702785 p. Réf. HAL: inserm-03319344

Lugat A., Hulo P., Ansquer C., Touchefeu Y., Mirallié E., Bennouna J., Drui D.,  Carcinoembryonic Antigen Increase in a Patient with Colon Cancer Who Have Achieved Complete Remission and Negative 18F-FDG PET/CT: Don’t Forget the Thyroid!. Current Oncology., 2021, vol 28, n°4, 2987 – 2992 p. Réf. HAL: inserm-03349985

Marazioti A., Krontira A. C, Behrend S. J, Giotopoulou G. A, Ntaliarda G., Blanquart C., Bayram H., Iliopoulou M., Vreka M., Trassl L., Pepe M. A A, Hackl C. M, Klotz L. V, Weiss S. A I, Koch I., Lindner M., Hatz R. A, Behr J., Wagner D. E, Papadaki H., Antimisiaris S. G, Jean D., Deshayes S., Grégoire M., Kayalar Ö., Mortazavi D., Dilege Ş., Tanju S., Erus S., Yavuz Ö., Bulutay P., Fırat P., Psallidas I., Spella M., Giopanou I., Lilis I., Lamort A., Stathopoulos G. T,  KRAS signaling in malignant pleural mesothelioma. EMBO Molecular Medicine., 2021, e13631. Réf. HAL: inserm-03483560

Ollivier L., Guimas V., Rio E., Vaugier L., Masson I., Libois V., Labbé M., Fradin D., Potiron V., Supiot S.,  Combination radiotherapy-immunotherapy in genitourinary cancer. Cancer Radiothérapie., 2021, vol 25, n°6-7, 565-569 p. Réf. HAL: inserm-03540455

Ollivier L., Labbé M., Fradin D., Potiron V., Supiot S.,  Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer. Frontiers in Oncology., 2021, vol 11, 744679 p. Réf. HAL: inserm-03369787

Paz-Ares L., Ciuleanu T.E., Cobo M., Schenker M., Zurawski B., Menezes J., Richardet E., Bennouna J., Felip E., Juan-Vidal O., Alexandru A., Sakai H., Lingua A., Salman P., Souquet P.J., De Marchi P., Martin C., Perol M., Scherpereel A., Lu S., Thomas J., Carbone D. P., Meadows-Shropshire S., Agrawal S., Oukessou A., Yan J., Reck M.,  First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial. The Lancet., 2021, vol 22, n°2, 198-211 p. Réf. HAL: inserm-03349944

Pons-Tostivint E., Lugat A., Fonteneau J.F., Denis M.G., Bennouna J.,  STK11/LKB1 Modulation of the Immune Response in Lung Cancer: From Biology to Therapeutic Impact. Cells., 2021, vol 10, n°11, 3129 p. Réf. HAL: inserm-03546835

Reck M., Ciuleanu T.E., Cobo M., Schenker M., Zurawski B., Janoski De Menezes J., Richardet E., Bennouna J., Felip E., Juan-Vidal O., Alexandru A., Sakai H., Scherpereel A., Lu S., Paz-Ares L., Carbone D.P., Memaj A., Marimuthu S., Tran P., John T.,  First-line nivolumab (NIVO) plus ipilimumab (IPI) plus two cycles of chemotherapy (chemo) versus chemo alone (4 cycles) in patients with advanced non-small cell lung cancer (NSCLC): Two-year update from CheckMate 9LA. Journal of Clinical Oncology., 2021, vol 39, n°15_suppl, 9000-9000 p. Réf. HAL: inserm-03540833

Reck M., Ciuleanu T.E., Cobo M., Schenker M., Zurawski B., Menezes J., Richardet E., Bennouna J., Felip E., Juan-Vidal O., Alexandru A., Sakai H., Lingua A., Reyes F., Souquet P.J., De Marchi P., Martin C., Pérol M., Scherpereel A., Lu S., Paz-Ares L., Carbone D., Memaj A., Marimuthu S., Zhang X., Tran P., John T.,  First-line nivolumab plus ipilimumab with two cycles of chemotherapy versus chemotherapy alone (four cycles) in advanced non-small-cell lung cancer: CheckMate 9LA 2-year update. ESMO Open., 2021, vol 6, n°5, 100273 p. Réf. HAL: inserm-03540859

Sun S., Frontini F., Qi W., Hariharan A., Ronner M., Wipplinger M., Blanquart C., Rehrauer H., Fonteneau J.F., Felley-Bosco E.,  Endogenous Retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development. Cancer Letters., 2021, vol 507, 26 – 38 p. Réf. HAL: inserm-03171655

Tournier P., Guicheux J., Paré A., Maltezeanu A., Blondy T., Veziers J., Vignes C., André M., Lesoeur J., Barbeito A. G., Bardonnet R., Blanquart C., Corre P., Geoffroy V., Weiss P., Gaudin A.,  A partially demineralized allogeneic bone graft: in vitro osteogenic potential and preclinical evaluation in two different intramembranous bone healing models. Scientific Reports., 2021, vol 11, n°1, 4907 p. Réf. HAL: inserm-03157874

Treps L., Declercq M., Bousfia S., Carmeliet P., Witters P.,  Comparative meta-analysis of cystic fibrosis cell models suggests partial endothelial-to-mesenchymal transition. Journal of Cystic Fibrosis., 2021, S1569-1993(21)00101-6. Réf. HAL: inserm-03349936

Treps L., Faure S., Clere N.,  Vasculogenic mimicry, a complex and devious process favoring tumorigenesis -Interest in making it a therapeutic target. Pharmacology & Therapeutics Part A Chemotherapy Toxicology and Metabolic Inhibitors., 2021, vol 223, 107805 p. Réf. HAL: inserm-03349934

Equipe 02 « Nuclear Oncology »

Al Tabaa Y., Bailly C., Kanoun S.,  FDG-PET/CT in Lymphoma: Where Do We Go Now? Cancers., 2021, vol 13, n°20, 5222 p. Réf. HAL: inserm-03540811

Alves F., Antunes I. F, Cazzola E., Cleeren F., Cornelissen B., Denkova A., Engle J., Faivre-Chauvet A., Gillings N., Hendrikx J. J M A, Jalilian A. R, Van Der Meulen N. P, Mikolajczak R., Neels O. C, Pillai M. R A, Reilly R., Rubow S., Seimbille Y., Spreckelmeyer S., Szymanski W., Taddei C.,  Highlight selection of radiochemistry and radiopharmacy developments by editorial board. European Association of Nuclear Medicine, issuing body – EJNMMI radiopharmacy and chemistry., 2021, vol 6, 31 p. Réf. HAL: inserm-03338402

Ansquer C., Touchefeu Y., Faivre-Chauvet A., Leux C., Le Bras M., Régenet N., Fleury V., Maucherat B., Senellart H., Guyetant S., Carlier T., Scotet-Cérato E., Rauscher A., Frampas E., Kraeber-Bodéré F.,  Head-to-Head Comparison of 18F-DOPA PET/CT and 68Ga-DOTANOC PET/CT in Patients With Midgut Neuroendocrine Tumors. Clinical Nuclear Medicine., 2021, vol 46, n°3, 181-186 p. Réf. HAL: hal-03115018

Berdal M., Gouard S., Eychenne R., Marionneau-Lambot S., Croyal M., Faivre-Chauvet A., Chérel M., Gaschet J., Gestin J.F., Guérard F.,  Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies. Chemical Science ., 2021, vol 12, n°4, 1458-1468 p. Réf. HAL: inserm-03024891

Blanc-Durand P., Jégou S., Kanoun S., Berriolo-Riedinger A., Bodet-Milin C. M, Kraeber-Bodéré F., Carlier T., Le Gouill S., Casasnovas R.O., Meignan M., Itti E.,  Fully automatic segmentation of diffuse large B cell lymphoma lesions on 3D FDG-PET/CT for total metabolic tumour volume prediction using a convolutional neural network. European Journal of Nuclear Medicine and Molecular Imaging., 2021, 1362-1370 p. Réf. HAL: inserm-03006852

Bodet-Milin C., Faivre-Chauvet A., Carlier T., Ansquer C., Rauscher A., Frampas E., Toulgoat F., Masson D., Bourgeois M., Cerato E., Rohmer V., Couturier O., Drui D., Goldenberg D. M, Sharkey R. M, Barbet J., Kraeber-Bodere F.,  Anti-CEA Pretargeted Immuno-PET Shows Higher Sensitivity Than DOPA PET/CT in Detecting Relapsing Metastatic Medullary Thyroid Carcinoma: Post Hoc Analysis of the iPET-MTC Study. Journal of Nuclear Medicine., 2021, vol 62, n°9, 1221 – 1227 p. Réf. HAL: inserm-03349968

Buffet C., Leboulleux S., Kraeber-Bodéré F., Bodet-Milin C., Cabanes L., Dohan A., Leprince P., Schlumberger M., Huillard O., Groussin L.,  Cardiac Metastasis from Medullary Thyroid Cancers with Long-Term Survival under Vandetanib. European Thyroid Journal ., 2021, vol 10, n°6, 517-522 p. Réf. HAL: inserm-03547147

Capitao M., Perrin J., Simon S., Gouard S., Chouin N., Bruchertseifer F., Morgenstern A., Rbah-Vidal L., Chérel M., Scotet E., Labarrière N., Guilloux Y., Gaschet J.,  Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model. Cancers., 2021, vol 13, n°6, 1256 p. Réf. HAL: inserm-03171640

Chalampalakis Z., Stute S., Filipović M., Sureau F., Comtat C.,  Use of dynamic reconstruction for parametric Patlak imaging in dynamic whole body PET. Physics in Medicine and Biology., 2021, vol 66, n°18, 185017 p. Réf. HAL: inserm-03547085

Chevalme Y.M., Boudali L., Gauthé M., Rousseau C., Skanjeti A., Merlin C., Robin P., Giraudet A.L., Janier M., Talbot J.N.,  Survey by the French Medicine Agency (ANSM) of the imaging protocol, detection rate, and safety of 68Ga-PSMA-11 PET/CT in the biochemical recurrence of prostate cancer in case of negative or equivocal 18F-fluorocholine PET/CT: 1084 examinations. European Journal of Nuclear Medicine and Molecular Imaging., 2021, Online ahead of print. Réf. HAL: inserm-03109828

Corroyer-Dulmont A., Jaudet C., Frelin A.M., Fantin J., Weyts K., Vallis K. A, Falzone N., Sibson N. R, Chérel M., Kraeber-Bodéré F., Batalla A., Bardet S., Bernaudin M., Samuel V.,  Radioimmunotherapy for Brain Metastases: The Potential for Inflammation as a Target of Choice. Frontiers in Oncology., 2021, vol 11, 714514 p. Réf. HAL: hal-03335353

Dagallier C., Avry F., Touchefeu Y., Buron F., Routier S., Chérel M., Arlicot N.,  Development of PET Radioligands Targeting COX-2 for Colorectal Cancer Staging, a Review of in vitro and Preclinical Imaging Studies. Frontiers in Medicine., 2021, vol 8, 675209 p. Réf. HAL: inserm-03547127

Delage J. Anna, Faivre-Chauvet A., Barbet J., Fierle J. Katrin, Schaefer N., Coukos G., Viertl D., Dunn S. Mark, Gnesin S., Prior J. O,  Impact of DOTA Conjugation on Pharmacokinetics and Immunoreactivity of [177Lu]Lu-1C1m-Fc, an Anti TEM-1 Fusion Protein Antibody in a TEM-1 Positive Tumor Mouse Model. Pharmaceutics., 2021, vol 13, n°96, Online ahead of print. Réf. HAL: inserm-03109836

Delage J. Anna, Gnesin S., Prior J. O, Barbet J., Le Saëc P., Marionneau-Lambot S., Gouard S., Chérel M., Bourgeois M., Schaefer N., Viertl D., Fierle J. Katrin, Dunn S. Mark, Faivre-Chauvet A.,  Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety. Cancers., 2021, vol 13, n°23, 5936 p. Réf. HAL: inserm-03541418

Deshayes R., Eustache M., Moreau A., Péterlin P., Néel A., Masseau A., Bodet-Milin C., Hamidou M.,  Systemic Rosai-Dorfman-Destombes disease associated with a myelodysplastic syndrome. Efficacy of hematologic treatment. La Revue De Médecine Interne., 2021, vol 42, n°4, 281-284 p. Réf. HAL: inserm-03546894

Espitia O., Schanus J., Agard C., Kraeber-Bodéré F., Hersant J., Serfaty J.M., Jamet B.,  Specific features to differentiate Giant cell arteritis aortitis from aortic atheroma using FDG-PET/CT. Scientific Reports., 2021, vol 11, n°1, 17389 p. Réf. HAL: inserm-03349976

Eychenne R., Chérel M., Haddad F., Guérard F., Gestin J.F.,  Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”. Pharmaceutics., 2021, vol 13, n°6, 906 p. Réf. HAL: inserm-03292397

Ferreira M., Lovinfosse P., Hermesse J., Decuypere M., Rousseau C., Lucia F., Schick U., Reinhold C., Robin P., Hatt M., Visvikis D., Bernard C., Leijenaar R. T H, Kridelka F., Lambin P., Meyer P. E, Hustinx R.,  [18F]FDG PET radiomics to predict disease-free survival in cervical cancer: a multi-scanner/center study with external validation. European Journal of Nuclear Medicine and Molecular Imaging., 2021, vol 48, n°11, 3432 – 3443 p. Réf. HAL: inserm-03541325

Filipović M., Dautremer T., Comtat C., Stute S., Barat É.,  Reconstruction, analysis and interpretation of posterior probability distributions of PET images, using the posterior bootstrap. Physics in Medicine and Biology., 2021, vol 66, n°12, 125018 p. Réf. HAL: hal-03321853

Grémy O., Mougin-Degraef M., Devilliers K., Berdal M., Laroche P., Miccoli L.,  DTPA-Coated Liposomes as a New Delivery Vehicle for Plutonium Decorporation. Radiation Research., 2021,. Réf. HAL: inserm-03540754

Guérard F., Maingueneau C., Liu L., Eychenne R., Gestin J.F., Montavon G. F, Galland N.,  Advances in the chemistry of astatine and implications for the development of radiopharmaceuticals. Accounts of Chemical Research., 2021, vol 54, n°16, 3264 p. Réf. HAL: inserm-03290202

Jalilian A., Gizawy M., Alliot C., Takacs S., Chakarborty S., Rovais M.R., Pupillo G., Nagatsu K., Park J., Khandaker M.U., Mikolajczak R., Bilewicz A., Okarvi S., Gagnon K., Al Rayyes A., Lapi S., Starovoitova V., Korde A., Osso J.,  IAEA Activities on 67Cu, 186Re, 47Sc Theranostic Radionuclides and Radiopharmaceuticals. Current Radiopharmaceuticals., 2021, vol 14, n°4, 306-314 p. Réf. HAL: inserm-03542554

Jamet B., Morvan L., Nanni C., Michaud A.V., Bailly C., Chauvie S., Moreau P., Touzeau C., Zamagni E., Bodet-Milin C., Kraeber-Bodéré F., Mateus D., Carlier T.,  Random survival forest to predict transplant-eligible newly diagnosed multiple myeloma outcome including FDG-PET radiomics: a combined analysis of two independent prospective European trials. European Journal of Nuclear Medicine and Molecular Imaging., 2021, vol 48, n°4, 1005-1015 p. Réf. HAL: inserm-03498841

Knighton R. C, Troadec T., Mazan V., Le Saëc P., Marionneau-Lambot S., Le Bihan T., Saffon‐merceron N., Le Bris N., Chérel M., Faivre-Chauvet A., Elhabiri M., Charbonnière L. J, Tripier R.,  Cyclam-Based Chelators Bearing Phosphonated Pyridine Pendants for 64 Cu-PET Imaging: Synthesis, Physicochemical Studies, Radiolabeling, and Bioimaging. Inorganic Chemistry., 2021, vol 60, n°4, 2634–2648 p. Réf. HAL: hal-03123032

Lugat A., Hulo P., Ansquer C., Touchefeu Y., Mirallié E., Bennouna J., Drui D.,  Carcinoembryonic Antigen Increase in a Patient with Colon Cancer Who Have Achieved Complete Remission and Negative 18F-FDG PET/CT: Don’t Forget the Thyroid!. Current Oncology., 2021, vol 28, n°4, 2987 – 2992 p. Réf. HAL: inserm-03349985

Maingueneau C., Berdal M., Eychenne R., Gaschet J., Chérel M., Gestin J.F., Guérard F., Gestin J.F.,  211At and 125I‐labeling of (hetero)aryliodonium ylides: astatine wins again. Chemistry – A European Journal., 2021,. Réf. HAL: hal-03507646

Marotte L., Capitao M., Deleine C., Beauvais T., Cadiou G., Perrin J., Chérel M., Scotet E., Guilloux Y., Bruchertseifer F., Morgenstern A., Jarry A., Gaschet J., Labarrière N.,  Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes. OncoImmunology., 2021, vol 10, n°1, e1940676. Réf. HAL: inserm-03271847

Maucherat B., Varmenot N., Fleury V., Senellart H., Rousseau C.,  Effective Management of 177Lu-DOTA0-Tyr3-Octreotate Extravasation. Clinical Nuclear Medicine., 2021, vol 46, n°2, 144-145 p. Réf. HAL: inserm-03540776

Mazza M., Alliot C., Sinquin C., Colliec-Jouault S., Reiller P. E, Huclier-Markai S.,  Marine Exopolysaccharide Complexed With Scandium Aimed as Theranostic Agents. Molecules., 2021, vol 26, n°4, 1143 p. Réf. HAL: hal-03187695

Mikolajczak R., Huclier-Markai S., Alliot C., Haddad F., Szikra D., Forgacs V., Garnuszek P.,  Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements. EJNMMI Radiopharmacy and Chemistry., 2021, vol 6, n°1, 19 p. Réf. HAL: hal-03263851

Perrin J., Capitao M., Allard M., Chouin N., Gouard S., Marionneau-Lambot S., Louvet C., Donnadieu E., Bruchertseifer F., Morgenstern A., Chérel M., Gaschet J., Guilloux Y.,  Targeted alpha particle therapy remodels the tumor microenvironment and improves efficacy of immunotherapy. International Journal of Radiation Oncology, Biology, Physics., 2021, Online ahead of print. Réf. HAL: inserm-03403252

Peterlin P., Chevallier P., Knapper S., Collin M.,  FLT3 ligand in acute myeloid leukemia: a simple test with deep implications. Leukemia & lymphoma., 2021, vol 62, n°2, 264-270 p. Réf. HAL: inserm-03496910

Peterlin P., Gaschet J., Guillaume T., Garnier A., Eveillard M., Le Bourgeois A., Cherel M., Debord C., Le Bris Y., Theisen O., Godon C., Mahé B., Dubruille V., Wuilleme S., Touzeau C., Gastinne T., Blin N., Lok A., Tessoulin B., Le Gouill S., Moreau P., Béné M., Chevallier P.,  A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Medicine., 2021, vol 10, n°2, 642-648 p. Réf. HAL: inserm-03495750

Proisy M., Vivier P.H., Morel B., Bruneau B., Sembely-Taveau C., Vacheresse S., Devillers A., Lecloirec J., Bodet-Milin C., Dubois M., Hamonic S., Bajeux E., Ganivet A., Adamsbaum C., Treguier C.,  Whole-body MR imaging in suspected physical child abuse: comparison with skeletal survey and bone scintigraphy findings from the PEDIMA prospective multicentre study. European Radiology., 2021, Online ahead of print. Réf. HAL: inserm-03214574

Rousseau C., Le Thiec M., Maucherat B., Frindel M., Fleury V.,  Place de l’imagerie moléculaire dans la prise en charge du cancer de la prostate. Cancer Radiothérapie., 2021, vol 25, n°6-7, 663-666 p. Réf. HAL: inserm-03546721

Samarut E., Lugat A., Amelot A., Scharbarg E., Hadjadj S., Primot C., Loussouarn D., Thillays F., Buffenoir K., Cariou B., Drui D., Roualdes V.,  Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma. Journal of Neuro-Oncology., 2021, vol 152, n°1, 115 – 123 p. Réf. HAL: inserm-03349991

Séhédic D., Roncali L., Djoudi A., Buchtova N., Avril S., Chérel M., Boury F., Lacoeuille F., Hindré F., Garcion E.,  Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells. Frontiers in Bioengineering and Biotechnology., 2021,. Réf. HAL: inserm-03374695

Touchefeu Y., Bailly C., Frampas E., Eugène T., Rousseau C., Bourgeois M., Bossard C., Faivre-Chauvet A., Rauscher A., Masson D., David A., Cerato E., Carlier T. M, Sharkey R.M., Goldenberg D.M., Barbet J. M, Kraeber-Bodéré F., Bodet-Milin C.,  Promising clinical performance of pretargeted immuno-PET with anti-CEA bispecific antibody and gallium-68-labelled IMP-288 peptide for imaging colorectal cancer metastases: a pilot study. European Journal of Nuclear Medicine and Molecular Imaging., 2021, vol 48, 874-882 p. Réf. HAL: inserm-02923408

Equipe 03 « Senescence escape and soluble markers of cancer progression »

Guillon J., Coquelet H., Leman G., Toutain B., Petit C., Henry C., Boissard A., Guette C., Coqueret O.,  tRNA biogenesis and specific aminoacyl-tRNA synthetases regulate senescence stability under the control of mTOR. PLoS Genetics., 2021, vol 17, n°12, e1009953. Réf. HAL: inserm-03524431

Maarouf A., Boissard A., Henry C., Leman G., Coqueret O., Guette C., Lelièvre E.,  Anterior gradient protein 2 is a marker of tumor aggressiveness in breast cancer and favors chemotherapy‑induced senescence escape. International Journal of Oncology., 2021, vol 60, n°1, 5 p. Réf. HAL: inserm-03524450

Orre C., Dieu X., Guillon J., Gueguen N., Ahmadpour S.T., Dumas J.F., Khiati S., Reynier P., Lenaers G., Coqueret O., Chevrollier A., Mirebeau-Prunier D., Desquiret-Dumas V.,  The Long Non-Coding RNA SAMMSON Is a Regulator of Chemosensitivity and Metabolic Orientation in MCF-7 Doxorubicin-Resistant Breast Cancer Cells. Biology., 2021, vol 10, n°11, 1156 p. Réf. HAL: inserm-03546999

Pouliquen D. L, Boissard A., Henry C., Blandin S., Coqueret O., Guette C.,  Lymphoid Organ Proteomes Identify Therapeutic Efficacy Biomarkers following the Intracavitary Administration of Curcumin in a Highly Invasive Rat Model of Peritoneal Mesothelioma. International Journal of Molecular Sciences., 2021, vol 22, n°16, 8566 p. Réf. HAL: inserm-03331998

Pouliquen D. L, Kopecka J.,  Malignant Mesothelioma. Cancers., 2021, vol 13, 3447 p. Réf. HAL: inserm-03287907

Equipe 04 « Innate Immunity and Immunotherapy »

Adam C., Paolini L., Gueguen N., Mabilleau G., Preisser L., Blanchard S. J., Pignon P., Manero F., Le Mao M., Morel A., Reynier P., Beauvillain C., Delneste Y., Procaccio V., Jeannin P.,  Acetoacetate protects macrophages from lactic acidosis-induced mitochondrial dysfunction by metabolic reprograming. Nature Communications., 2021, vol 12, n°1, 7115 p. Réf. HAL: inserm-03471979

Alary A.S., Maute C., Kosmider O., Sujobert P., Gauthier A., Macintyre E., Preudhomme C., Hayette S., Luque-Paz D., Baran-Marszak F., Davi F., Lippert E., Cornillet-Lefebvre P., Delfau-Larue M.H., Cassinat B., Cayuela J.M., Flandrin-Gresta P.,  Improvement of Standardization of Molecular Analyses in Hematology: The 10-year GBMHM French Experience. HemaSphere., 2021, vol 5, n°12, e658. Réf. HAL: hal-03464576

Augusto J., Gatault P., Sayegh J., Garnier A., Duveau A., Merieau E., Bailly E., Subra J., Büchler M.,  Successful treatment of acute kidney allograft rejection using extracorporeal photopheresis in the context of post‐transplant lymphoproliferative diseases: three successive cases. Transplant International., 2021, vol 34, n°11, 2415 – 2417 p. Réf. HAL: inserm-03549859

Augusto J.F., Langs V., Demiselle J., Lavigne C., Brilland B., Duveau A., Poli C., Chevailler A., Croue A., Tollis F., Sayegh J., Subra J.F.,  Low Serum Complement C3 Levels at Diagnosis of Renal ANCA-Associated Vasculitis Is Associated with Poor Prognosis. PLoS ONE., 2021, vol 11, n°7, e0158871. Réf. HAL: inserm-03549837

Baroud M., Lepeltier E., El-Makhour Y., Lautram N., Bejaud J., Thepot S., Duval O.,  Azacitidine Omega-3 Self-Assemblies: Synthesis, Characterization, and Potent Applications for Myelodysplastic Syndromes. Pharmaceuticals., 2021, vol 14, n°12, 1317 p. Réf. HAL: hal-03534533

Baroud M., Lepeltier E., Thepot S., El-Makhour Y., Duval O.,  The evolution of nucleosidic analogues: self-assembly of prodrugs into nanoparticles for cancer drug delivery. Nanoscale Advances., 2021, vol 3, n°8, 2157 – 2179 p. Réf. HAL: hal-03448613

Benameur T., Soleti R., Panaro M.A., La Torre M.E., Monda V., Messina G., Porro C.,  Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain. Molecules., 2021, vol 26, n°16, 4794 p. Réf. HAL: inserm-03424123

Benameur T., Soleti R., Porro C.,  The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases. Nutrients., 2021, vol 13, n°4, 1318 p. Réf. HAL: inserm-03424126

Billaud A., Chevalier L.M., Augereau P., Frenel J.S., Passot C., Campone M., Morel A.,  Functional pre-therapeutic evaluation by genome editing of variants of uncertain significance of essential tumor suppressor genes. Genome Medicine., 2021, vol 13, n°1, 174 p. Réf. HAL: inserm-03426300

Blatzer M., Papon N., Delneste Y., Latgé J.P.,  Macrophages: Checking Toxicity of Fungal Metabolites in the Colon. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism ., 2021, vol 32, n°2, 63-65 p. Réf. HAL: hal-03086214

Brampton C., Pomozi V., Chen L.H., Apana A., Mccurdy S., Zoll J., Boisvert W., Lambert G., Henrion D., Blanchard S. J., Kuo S., Leftheriotis G., Martin L., Le Saux O.,  ABCC6 deficiency promotes dyslipidemia and atherosclerosis. Scientific Reports., 2021, vol 11, n°1, 3881 p. Réf. HAL: inserm-03547172

Brilland B., Bach-Bunner M., Gomes C.N., Larochette V., Foucher E., Plaisance M., Saulnier P., Costedoat-Chalumeau N., Ghillani P., Belizna C., Delneste Y., Augusto J.F., Jeannin P.,  Serum Interleukin-26 Is a New Biomarker for Disease Activity Assessment in Systemic Lupus Erythematosus. Frontiers in Immunology., 2021, vol 12, 663192 p. Réf. HAL: inserm-03267806

Brilland B., Vinatier E., Subra J.F., Jeannin P., Augusto J.F., Delneste Y.,  Anti-Pentraxin Antibodies in Autoimmune Diseases: Bystanders or Pathophysiological Actors? Frontiers in Immunology., 2021, Online ahead of print. Réf. HAL: inserm-03142425

Buffet C., Leboulleux S., Kraeber-Bodéré F., Bodet-Milin C., Cabanes L., Dohan A., Leprince P., Schlumberger M., Huillard O., Groussin L.,  Cardiac Metastasis from Medullary Thyroid Cancers with Long-Term Survival under Vandetanib. European Thyroid Journal ., 2021, vol 10, n°6, 517-522 p. Réf. HAL: inserm-03547147

Gilbert C., Lefeuvre C., Preisser L., Pivert A., Soleti R., Blanchard S., Delneste Y., Ducancelle A., Couez D., Jeannin P.,  Age-Related Expression of IFN-l1 Versus IFN-I and Beta-Defensins in the Nasopharynx of SARS-CoV-2-Infected Individuals. Frontiers in Immunology., 2021, vol 12, Online ahead of print. Réf. HAL: inserm-03424095

Goldman G., Delneste Y., Papon N.,  Fungal Polysaccharides Promote Protective Immunity. Trends in Microbiology., 2021, vol 29, n°5, 379-381 p. Réf. HAL: hal-03208146

Jourdain P., Brilland B., Medhioub O., Caron J., Samoreau C., Djema A., Gansey R., Coindre J.P., Cousin M., Garnier A.S., Henry N., Wacrenier S., Riou J., Piccoli G.B., Augusto J.F.,  Incidence and Temporal Trend in Risk Factors of Severe Infections in ANCA-Glomerulonephritis Patients. Kidney International Reports., 2021, vol 6, n°4, 1161-1165 p. Réf. HAL: inserm-03267787

Jullien M., Orvain C., Berceanu A., Couturier M.A., Guillaume T., Peterlin P., Garnier A., Bourgeois A. Le, Klemencie M., Schmidt A., Hunault M., Daguindau E., Roussel X., Delepine P., Guillerm G., Giltat A., François S., Thepot S., Gouill S. Le, Béné M.C., Chevallier P.,  Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis. Transplantation and Cellular Therapy., 2021, vol 27, n°10, 861.e1 – 861.e7 p. Réf. HAL: inserm-03436123

Kime A., Bréal C., Cottereau A.S., Friedrich C., Decroocq J., Kaltenbach S., Lupo A., Copin M.C., Pasmant E., Deschamps P., Emile J.F., Bouscary D., Burroni B.,  Malignant histiocytosis with a Langerhans cell subtype: A report on the diagnostic and therapeutic challenge. Blood Cells, Molecules and Diseases., 2021, vol 92, 102623 p. Réf. HAL: inserm-03549848

Korkmaz B., Lamort A.S., Domain R., Beauvillain C., Gieldon A., Yildirim A.Ö., Stathopoulos G., Rhimi M., Jenne D., Kettritz R.,  Cathepsin C inhibition as a potential treatment strategy in cancer. Biochemical Pharmacology., 2021, vol 194, 114803 p. Réf. HAL: inserm-03547138

Lacombe V., Nunes Gomes C., Robin J., Thépot S., François S., Cottin L., Ugo V., Dieu X., Abgueguen P., Daniel V., Giltat A., Hunault M., Riou J., Orvain C., Schmidt A.,  Risk of infection according to the gamma globulin level in the 100 days following allogeneic stem cell transplantations. European Journal of Haematology., 2021, Online ahead of print. Réf. HAL: inserm-03315916

Largeaud L., Cornillet-Lefebvre P., Hamel J.F., Dumas P.Y., Prade N., Dufrechou S., Plenecassagnes J., Luquet I., Blanchet O., Banos A., Béné M., Bernard M., Bertoli S., Bonmati C., Fornecker L.M., Guièze R., Haddaoui L., Hunault M., Ianotto J.C., Jourdan E., Ojeda M., Peterlin P., Vey N., Zerazhi H., Yosr H., Mineur A., Cahn J.Y., Ifrah N., Récher C., Pigneux A., Delabesse E., Marolleau J.P., Aleme A., Orsini-Piocelle F., Cadoux N., Marie C., Al jijakli A., Lepeu G., Beyrne M., Labarrere S., Deconinck E., Peria M., El Yamani A., Kadiri O., Choufi B., Brument M., Leguay T., Berthou C., Guillerm G., Drugmanne G., Tournilhac O., Roy G., Audhuy B., Camara S., Caillot D., Grandjean M., Bulabois C.E., Fief B., Ladraa C., Dorvaux V., Hagopian M., Fegueux N., Fenoll C., Sabadash V., Haby C., Witz F., Lhuire M., Delaunay J., Airiau L., Mannone L., Touitou I., Umuhire D., Alexis M., Michel O., Dreyfus F., Bouscary D., Cheung A., Sanhes L., Touhami F., Ribas E., Puyade M., Gallego-Hernanz M.P., Hugon N., Himberlin C., Maggi L., Lamy T., Testu A., Tavernier E., Marchand S., Lioure B., Kravanja C., Benboubker L., Nollet D., Attal M., Sarry A., Lhermitte A., Yrica G., Schwartz D., Le Montagner N., Auvray L., Delepine R., Fayault A.,  Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study. Leukemia., 2021, vol 35, n°5, 1291-1300 p. Réf. HAL: hal-03441014

Lemoine S., Renard M., Bouvier A., Orvain C., Giltat A., Cottin L., Blanchet O., Hunault-Berger M., Ugo V., Luque Paz D.,  No detection of atypical one-base deletion of CALR exon 9 with fragment analysis: A molecular trap to avoid. Blood Cells, Molecules and Diseases., 2021, vol 90, 102589 p. Réf. HAL: inserm-03315920

Luque Paz D., Cottin L., Lippert E., Robin J.B., Bescond C., Genevieve F., Boyer F., Quintin-Roue I., Rousselet M.C., Burroni B., Hunault-Berger M., Ugo V., Ianotto J.C., Orvain C.,  Different number of circulating CD34 + cells in essential thrombocythemia, prefibrotic/early primary myelofibrosis, and overt primary myelofibrosis. Annals of Hematology., 2021, Online ahead of print. Réf. HAL: inserm-03549785

Luque Paz D., Riou J., Verger E., Cassinat B., Chauveau A., Ianotto J.C., Dupriez B., Boyer F., Renard M., Mansier O., Murati A., Rey J., Etienne G., Mansat-De Mas V., Tavitian S., Nibourel O., Girault S., Le Bris Y., Girodon F., Ranta D., Chomel J.C., Cony-Makhoul P., Sujobert P., Robles M., Ben Abdelali R., Kosmider O., Cottin L., Roy L., Sloma I., Vacheret F., Wemeau M., Mossuz P., Slama B., Cussac V., Denis G., Walter-Petrich A., Burroni B., Jézéquel N., Giraudier S., Lippert E., Socié G., Kiladjian J.J., Ugo V.,  Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study. Blood Advances., 2021, vol 5, 1442 – 1451 p. Réf. HAL: inserm-03187575

Mabilleau G., Delneste Y., Papon N.,  Predicting Bone Regeneration with a Simple Blood Test. Trends in Molecular Medicine., 2021,. Réf. HAL: hal-03208763

Moulin C., Guillemin F., Remen T., Bouclet F., Hergalant S., Quinquenel A., Dartigeas C., Tausch E., Lazarian G., Blanchet O., Lomazzi S., Chapiro E., Schneider C., Nguyen‐khac F., Davi F., Hunault M., Tomowiak C., Roos‐weil D., Siebert R., Thieblemont C., Cymbalista F., Laribi K., Béné M., Stilgenbauer S., Guièze R., Feugier P., Broséus J.,  Clinical, biological, and molecular genetic features of Richter syndrome and prognostic significance: a study of the French Innovative Leukemia Organization. American Journal of Hematology., 2021, vol 96, n°9, E311-E314. Réf. HAL: hal-03238759

Orvain C., Kiger L., Peronet I., Peron A., Galacteros F., Wajcman H., Pissard S.,  Hb Angers: A new α2‐globin variant [α2 (140)(HC2) Tyr → Ser; HBA2 : C.422 A>C] with increased oxygen affinity leading to erythrocytosis. International Journal of Laboratory Hematology., 2021, vol 43, n°3, e114-e117. Réf. HAL: inserm-03497443

Pellier I., Miot C., Mahlaoui N., Fischer A.,  Wiskott-Aldrich syndrome. Hématologie., 2021, vol 27, 78 – 94 p. Réf. HAL: inserm-03549780

Prat M., Salon M., Allain T., Dubreuil O., Noël G., Preisser L., Jean B., Cassard L., Lemée F., Tabah-Fish I., Pipy B., Jeannin P., Prost J.F., Barret J.M., Coste A.,  Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation. Cancers., 2021, vol 13, n°8, 1845 p. Réf. HAL: inserm-03215770

Staerck C., Yaakoub H., Vandeputte P., Tabiasco J., Godon C., Gastebois A., Giraud S., Guillemette T., Calenda A., Delneste Y., Fleury M., Bouchara J.P.,  The Glycosylphosphatidylinositol-Anchored Superoxide Dismutase of Scedosporium apiospermum Protects the Conidia from Oxidative Stress. Journal of Fungi., 2021, vol 7, n°28, 8697-8710 p. Réf. HAL: inserm-03309902

Sureau L., Orvain C., Ianotto J.C., Ugo V., Kiladjian J.J., Luque Paz D., Riou J.,  Efficacy and tolerability of Janus kinase inhibitors in myelofibrosis: a systematic review and network meta-analysis. Blood Cancer Journal., 2021, vol 11, n°7, 135 p. Réf. HAL: inserm-03315915

Vantyghem S., Peterlin P., Thépot S., Ménard A., Dubruille V., Debord C., Guillaume T., Garnier A., Le Bourgeois A., Wuilleme S., Godon C., Theisen O., Eveillard M., Delaunay J., Maisonneuve H., Morineau N., Villemagne B., Vigouroux S., Subiger F., Lestang E., Loirat M., Parcelier A., Godmer P., Mercier M., Trebouet A., Paz D. Luque, Le Calloch R., Le Clech L., Bossard C., Moreau A., Ugo V., Hunault M., Moreau P., Le Gouill S., Chevallier P., Béné M. C, Le Bris Y.,  Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica., 2021, vol 106, n°3, 701-707 p. Réf. HAL: inserm-02552097

Vergne C., Blin N., Mallet J., Thomas B., Moles M.P., Schmidt A., Proust S.,  Transition to adulthood: An essential period in the follow up of young patients. Bulletin du Cancer., 2021, vol 108, n°2, 151-158 p. Réf. HAL: inserm-03547057

Wacrenier S., Boud’hors C., Piccoli G. Barbara, Augusto J., Brilland B.,  Commentary: Predictors of Biopsy-Proven Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis. Frontiers in Immunology., 2021, vol 12, 691179 p. Réf. HAL: inserm-03549752

Wicker‐planquart C., Tacnet‐delorme P., Preisser L., Dufour S., Delneste Y., Housset D., Frachet P., Thielens N. M.,  Insights into the ligand binding specificity of SREC‐II (scavenger receptor expressed by endothelial cells). FEBS Open Bio., 2021, Online ahead of print. Réf. HAL: inserm-03315913

Equipe 05 « Design and application of innovative loco-regional Treatments in Glioblastoma »

Ah-Pine F., Casas D., Menei P., Boisselier B., Garcion E., Rousseau A.,  RNA-sequencing of IDH-wild-type glioblastoma with chromothripsis identifies novel gene fusions with potential oncogenic properties. Translational Oncology., 2021, vol 14, n°1, 100884 p. Réf. HAL: inserm-03546822

Alzial G., Renoult O., Paris F., Gratas C., Clavreul A., Pecqueur C.,  Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma. Oncogene., 2021, Online ahead of print. Réf. HAL: inserm-03434277

Berro D. Hassanein, Lemée J.M., Leiber L.M., Emery E., Menei P., Ter Minassian A.,  Overt speech critically changes lateralization index and did not allow determination of hemispheric dominance for language: an fMRI study. BMC Neuroscience., 2021, vol 22, n°1, 74 p. Réf. HAL: inserm-03474160

Bouron C., Mathie C., Morel O., Seegers V., Guillerminet C., Lacoeuille F., Patsouris A., Testard A.,  Correlation between baseline 18F-FDG PET/CT features and pathological complete response after neoadjuvant chemotherapy in early triple negative breast cancer. Médecine Nucléaire., 2021, vol 45, n°3, 135-141 p. Réf. HAL: inserm-03540483

Casanova M., Clavreul A., Soulard G., Delion M., Aubin G., Ter Minassian A., Seguier R., Menei P.,  Immersive Virtual Reality and Ocular Tracking for Brain Mapping During Awake Surgery: Prospective Evaluation Study. Journal of Medical Internet Research., 2021, vol 23, n°3, e24373. Réf. HAL: inserm-03375816

Clavreul A., Aubin G., Delion M., Lemée J.M., Ter Minassian A., Menei P.,  What effects does awake craniotomy have on functional and survival outcomes for glioblastoma patients? Journal of Neuro-Oncology., 2021, vol 151, 113 – 121 p. Réf. HAL: inserm-03374663

Clavreul A., Lemée J.M., Soulard G., Rousseau A., Menei P.,  A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide. Cancers., 2021, vol 13, n°22, 5778 p. Réf. HAL: inserm-03547180

Lemée J.M., Chinier E., Bernard F., Gallet C., Menei P.,  Intrathecal baclofen infusion for spastic intractable hiccups. Annals of Physical and Rehabilitation Medicine., 2021, vol 64, n°4, 101417 p. Réf. HAL: inserm-03546632

Molina-Peña R., Haji Mansor M., Najberg M., Thomassin J.M., Gueza B., Alvarez-Lorenzo C., Garcion E., Jérôme C., Boury F.,  Nanoparticle-containing electrospun nanofibrous scaffolds for sustained release of SDF-1α. International Journal of Pharmaceutics., 2021, vol 610, 121205 p. Réf. HAL: inserm-03546708

Pagès M., Uro-Coste E., Colin C., Meyronet D., Gauchotte G., Maurage C.A., Rousseau A., Godfraind C., Mokhtari K., Silva K., Figarella‑branger D., Varlet P.,  The Implementation of DNA Methylation Profiling into a Multistep Diagnostic Process in Pediatric Neuropathology: A 2-Year Real-World Experience by the French Neuropathology Network. Cancers., 2021, vol 13, n°6, 1377 p. Réf. HAL: hal-03190280

Rmaidi A., Zelzer M., Sindji L., Dima R., Boury F., Delorme N., Montero-Menei C.,  Impact of the physico-chemical properties of polymeric microspheres functionalized with cell adhesion molecules on the behavior of mesenchymal stromal cells. Materials Science and Engineering: C., 2021, vol 121, 111852 p. Réf. HAL: inserm-03549782

Séhédic D., Roncali L., Djoudi A., Buchtova N., Avril S., Chérel M., Boury F., Lacoeuille F., Hindré F., Garcion E.,  Rapamycin-Loaded Lipid Nanocapsules Induce Selective Inhibition of the mTORC1-Signaling Pathway in Glioblastoma Cells. Frontiers in Bioengineering and Biotechnology., 2021,. Réf. HAL: inserm-03374695

Simion V., Loussouarn C., Laurent Y., Roncali L., Gosset D., Reverchon F., Rousseau A., Martin F., Midoux P., Pichon C., Garcion E., Baril P.,  LentiRILES, a miRNA-ON Sensor System for Monitoring the Functionality of miRNA in Cancer Biology and Therapy. RNA Biology/RNA Biol.., 2021, Online ahead of print. Réf. HAL: inserm-03374619

Toullec C., Le Bideau J., Geoffroy V., Halgand B., Buchtova N., Molina-Peña R., Garcion E., Avril S., Sindji L., Dube A., Boury F., Jérôme C.,  Curdlan–Chitosan Electrospun Fibers as Potential Scaffolds for Bone Regeneration. Polymers., 2021, vol 13, 526 p. Réf. HAL: inserm-03137953

Equipe 06 « Signaling in Oncogenesis, Angiogenesis and Permeability »

Ghoroghi S., Mary B., Larnicol A., Asokan N., Klein A., Osmani N., Busnelli I., Delalande F., Paul N., Halary S., Gros F., Fouillen L., Haeberle A.M., Royer C., Spiegelhalter C., André-Grégoire G. M, Mittelheisser V., Detappe A., Murphy K., Timpson P., Carapito R., Blot-Chabaud M., Gavard J., Carapito C., Vitale N., Lefebvre O., Goetz J.G., Hyenne V.,  Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes. eLife., 2021, n°10, e61539. Réf. HAL: inserm-03103515

Huna A., Nawrocki-Raby B., Padilla-Benavides T., Gavard J., Coscoy S., Bernard D., Boissan M.,  Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial–Mesenchymal State in Cancer Cells. International Journal of Molecular Sciences., 2021, vol 22, n°7, 3718 p. Réf. HAL: inserm-03191241

Mancini S. Jc, Balabanian K., Corre I., Gavard J., Le Bousse-Kerdilès M.C., Lazennec G., Louache F., Maguer-Satta V., Mazure N. M, Mechta-Grigoriou F., Peyron J.F., Trichet V., Herault O.,  Deciphering tumor niches: lessons from solid and hematological malignancies. Frontiers in Immunology., 2021,. Réf. HAL: hal-03401194

Pollock L., Jardine J., Urbé S., Clague M.,  The PINK1 repertoire: Not just a one trick pony. BioEssays., 2021, vol 43, n°11, 2100168 p. Réf. HAL: inserm-03547012

Renaud C., Bidère N.,  Function of Centriolar Satellites and Regulation by Post-Translational Modifications. Frontiers in Cell and Developmental Biology., 2021, vol 9, 780502 p. Réf. HAL: inserm-03540899

Rosińska S., Gavard J.,  Tumor Vessels Fuel the Fire in Glioblastoma. International Journal of Molecular Sciences., 2021, vol 22, n°12, 6514 p. Réf. HAL: inserm-03265068

Sabbagh Q., André-Grégoire G., Alves-Nicolau C., Dupont A., Bidère N., Jouglar E., Guével L., Frénel J.S., Gavard J.,  The von Willebrand Factor stamps Plasmatic Extracellular Vesicles from Glioblastoma Patients. Scientific Reports., 2021, vol 11, n°1, 22792 p. Réf. HAL: inserm-03379903

Silva A.R., Lima D., Kurt L., Dupré M., Chamot-Rooke J., Santos M.D., Nicolau C.A., Valente R.H., Barbosa V., Carvalho P.,  Leveraging the partition selection bias to achieve a high-quality clustering of mass spectra. Journal of Proteomics., 2021, vol 245, 104282 p. Réf. HAL: pasteur-03441752

Thys A., Trillet K., Rosinska S., Gayraud A., Douanne T., Danger Y., Renaud C.C.N., Antigny L., Lavigne R., Pineau C., Com E., Vérité F., Gavard J., Bidère N.,  Serine 165 phosphorylation of SHARPIN regulates the activation of NF-κB. iScience., 2021, vol 24, n°1, 101939 p. Réf. HAL: hal-03099208

Trillet K., Jacobs K., André-Grégoire G., Thys A., Maghe C., Cruard J., Minvielle S., Diest S.G., Montagnac G., Bidère N., Gavard J.,  The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR. Journal of Cell Biology., 2021, vol 220, n°9, e202004114. Réf. HAL: inserm-03340113

Vitale D., Icardi A., Rosales P., Spinelli F., Sevic I., Alaniz L.,  Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy. Frontiers in Oncology., 2021, vol 11, 710061 p. Réf. HAL: inserm-03546901

Equipe 07 « Stress Adaptation and Tumor Escape »

Beaudu-Lange C., Larrat S., Lange E., Lecoq K., Nguyen F.,  Prevalence of Reproductive Disorders including Mammary Tumors and Associated Mortality in Female Dogs. Veterinary Sciences., 2021, vol 8, n°9, 184 p. Réf. HAL: inserm-03546741

Bertho M., Patsouris A., Augereau P., Robert M., Frenel J.S., Blonz C., Campone M.,  A pharmacokinetic evaluation of alpelisib for the treatment of HR+, HER2-negative, PIK3CA-mutated advanced or metastatic breast cancer. Expert Opinion on Drug Metabolism and Toxicology., 2021, vol 17, n°2, 139-152 p. Réf. HAL: inserm-03495760

Bouhsina N., Decante C., Hardel J. B, Madec S., Abadie J., Hamel A., Le Visage C., Lesoeur J., Guicheux J., Clouet J., Fusellier M.,  Correlation between magnetic resonance, X-ray imaging alterations and histological changes in an ovine model of age-related disc degeneration. eCells and Materials Journal., 2021, vol 42, 166 – 178 p. Réf. HAL: inserm-03367848

Chocteau F., Mordelet V., Dagher E., Loussouarn D., Abadie J., Nguyen F.,  One‐year conditional survival of dogs and cats with invasive mammary carcinomas: A concept inspired from human breast cancer. Veterinary and Comparative Oncology., 2021, vol 19, n°1, 140-151 p. Réf. HAL: inserm-03498493

Colombié M., Jézéquel P., Rubeaux M., Frenel J.S., Bigot F., Seegers V., Campone M.,  The EPICURE study: a pilot prospective cohort study of heterogeneous and massive data integration in metastatic breast cancer patients. BMC Cancer., 2021, vol 21, n°1, 333 p. Réf. HAL: inserm-03218545

Duclos M., Prigent C., Le Borgne R., Guen V.J.,  Three-Dimensional Imaging of Organoids to Study Primary Ciliogenesis During ex vivo Organogenesis. Journal of visualized experiments : JoVE., 2021,. Réf. HAL: hal-03260699

Jézéquel P., Gouraud W., Azzouz F.B., Basseville A., Juin P., Lasla H., Campone M.,  Interest of the bc-GenExMiner web tool in oncology. Bulletin du Cancer., 2021, vol 108, n°11, 1057-1064 p. Réf. HAL: inserm-03542578

Jézéquel P., Gouraud W., Ben Azzouz F., Guérin-Charbonnel C., Juin P., Lasla H., Campone M.,  bc-GenExMiner 4.5: new mining module computes breast cancer differential gene expression analyses. Database – The journal of Biological Databases and Curation., 2021, vol 2021, baab007. Réf. HAL: inserm-03349355

Lavy M., Gauttier V., Poirier N., Barillé-Nion S. C, Blanquart C.,  Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities. Frontiers in Immunology., 2021, vol 12, 702785 p. Réf. HAL: inserm-03319344

Nguyen J.M., Jézéquel P., Gillois P., Silva L., Ben Azzouz F., Lambert-Lacroix S., Juin P., Campone M., Gaultier A., Moreau-Gaudry A., Antonioli D.,  Random forest of perfect trees: concept, performance, applications and perspectives. Bioinformatics., 2021, vol 37, n°15, 2165-2174 p. Réf. HAL: inserm-03546813

Obiang E.O., Jézéquel P., Proïa F.,  A partial graphical model with a structural prior on the direct links between predictors and responses. ESAIM: Probability and Statistics., 2021, vol 25, 298-324 p. Réf. HAL: hal-02521004

Tea I., De Luca A., Schiphorst A.M., Grand M., Barillé-Nion S. C, Mirallié E., Drui D., Krempf M., Hankard R., Tcherkez G.,  Stable Isotope Abundance and Fractionation in Human Diseases. Metabolites., 2021, vol 11, n°6, 370 p. Réf. HAL: hal-03313301

Truchot Y., Dagher E., Abadie J., Nguyen F.,  Unfavorable Prognostic Effects of the Stem Cell Pluripotency Factor Sox2 in Feline Invasive Mammary Carcinomas. Frontiers in Veterinary Science., 2021, vol 7, 622019 p. Réf. HAL: inserm-03349326

Wilson M.M., Callens C., Le Gallo M., Mironov S., Ding Q., Salamagnon A., Chavarria T.E., Viel R., Peasah A.D., Bhutkar A., Martin S., Godey F., Tas P., Kang H.S., Juin P., Jetten A.M., Visvader J.E., Weinberg R.A., Attanasio M., Prigent C., Lees J.A., Guen V.J.,  An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis. Science Advances ., 2021, vol 7, n°44, eabf6063. Réf. HAL: hal-03420207

Equipe 08 « Integrative Cancer Genomics »

Annonay M., Gauquelin L., Geiss R., Ung M., Cristol-Dalstein L., Mouret-Reynier M.A., Goncalves A., Abadie-Lacourtoisie S., Francois E., Perrin C., Le Fel J., Lorgis V., Servent V., Uwer L., Jouannaud C., Leheurteur M., Joly F., Campion L., Courtinard C., Villacroux O., Petit T., Soubeyran P., Terret C., Bellera C., Brain E., Delaloge S.,  Treatment and outcomes of older versus younger women with HER2-positive metastatic breast cancer in the real-world national ESME database. Breast., 2021, vol 60, 138-146 p. Réf. HAL: hal-03468488

Canzian F., Piredda C., Macauda A., Zawirska D., Frost Andersen N., Nagler A., Zaucha J.M., Mazur G., Dumontet C., Wątek M., Jamroziak K., Sainz J., Varkonyi J., Butrym A., Beider K., Abildgaard N., Lesueur F., Dudziński M., Vangsted A.J., Pelosini M., Subocz E., Petrini M., Buda G., Raźny M., Gemignani F., Marques H., Orciuolo E., Kadar K., Jurczyszyn A., Druzd-Sitek A., Vogel U., Andersen H.V., Reis R.M., Suska A., Avet Loiseau H., Kruszewski M., Tomczak W., Rymko M., Minvielle S., Campa D.,  A polygenic risk score for multiple myeloma risk prediction. European Journal of Human Genetics., 2021, Online ahead of print. Réf. HAL: inserm-03480934

Chalopin T., Vallet N., Theisen O., Ochmann M., Tiab M., Godmer P., Barin C., Hérault O., Gyan E., Le Gouill S., Avet‐loiseau H., Benboubker L., Moreau P., Touzeau C.,  No survival improvement in patients with high‐risk multiple myeloma harbouring del(17p) and/or t(4;14) over the two past decades. British Journal of Haematology., 2021, vol 194, n°3, 635-638 p. Réf. HAL: inserm-03349139

Derrien J., Guérin-Charbonnel C., Gaborit V., Campion L., Devic M., Douillard E., Roi N., Avet-Loiseau H., Decaux O., Facon T., Mallm J.P., Eils R., Munshi N., Moreau P., Herrmann C., Magrangeas F., Minvielle S.,  The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability. Genome Medicine., 2021,. Réf. HAL: hal-03333684

Jullien M., Touzeau C., Moreau P.,  Monoclonal antibodies as an addition to current myeloma therapy strategies. Expert Review of Anticancer Therapy., 2021, vol 21, n°1, 33-43 p. Réf. HAL: inserm-03498459

Kaufman J. L, Gasparetto C., Schjesvold F. H, Moreau P., Touzeau C., Facon T., Boise L. H, Jiang Y., Yang X., Dunbar F., Vishwamitra D., Unger S., Macartney T., Pesko J., Yu Y., Salem A. Hamed, Ross J. A, Hong W., Maciag P. C, Pauff J. M, Kumar S.,  Targeting BCL ‐2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma. American Journal of Hematology., 2021, vol 96, n°4, 418 – 427 p. Réf. HAL: inserm-03349233

Laurent V., Fronteau C., Antier C., Dupuis P., Tessoulin B., Gastinne T., Mahé B., Blin N., Dubruille V., Lok A., Chevallier P., Guillaume T., Garnier A., Peterlin P., Le Bourgeois A., Vantyghem S., Tiab M., Godmer P., Sadot S., Loirat M., Trebouet A., Cormier N., Le Gouill S., Moreau P., Touzeau C.,  Autologous stem-cell collection following VTD or VRD induction therapy in multiple myeloma: a single-center experience. Bone Marrow Transplantation., 2021, vol 56, n°2, 395-399 p. Réf. HAL: inserm-03495985

Le Calvez B., Moreau P., Touzeau C.,  Immune checkpoint inhibitors for the treatment of myeloma: novel investigational options. Expert Opinion on Investigational Drugs., 2021, vol 30, n°9, 965-973 p. Réf. HAL: inserm-03349119

Peterlin P., Gaschet J., Guillaume T., Garnier A., Eveillard M., Le Bourgeois A., Cherel M., Debord C., Le Bris Y., Theisen O., Godon C., Mahé B., Dubruille V., Wuilleme S., Touzeau C., Gastinne T., Blin N., Lok A., Tessoulin B., Le Gouill S., Moreau P., Béné M., Chevallier P.,  A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Medicine., 2021, vol 10, n°2, 642-648 p. Réf. HAL: inserm-03495750

Touzeau C., Antier C., Moreau P.,  Carfilzomib in combination with daratumumab in the management of relapsed multiple myeloma. Future Oncology., 2021, vol 17, n°9, 993-998 p. Réf. HAL: inserm-03496299

Trillet K., Jacobs K., André-Grégoire G., Thys A., Maghe C., Cruard J., Minvielle S., Diest S.G., Montagnac G., Bidère N., Gavard J.,  The glycoprotein GP130 governs the surface presentation of the G protein–coupled receptor APLNR. Journal of Cell Biology., 2021, vol 220, n°9, e202004114. Réf. HAL: inserm-03340113

Vantyghem S., Peterlin P., Thépot S., Ménard A., Dubruille V., Debord C., Guillaume T., Garnier A., Le Bourgeois A., Wuilleme S., Godon C., Theisen O., Eveillard M., Delaunay J., Maisonneuve H., Morineau N., Villemagne B., Vigouroux S., Subiger F., Lestang E., Loirat M., Parcelier A., Godmer P., Mercier M., Trebouet A., Paz D. Luque, Le Calloch R., Le Clech L., Bossard C., Moreau A., Ugo V., Hunault M., Moreau P., Le Gouill S., Chevallier P., Béné M. C, Le Bris Y.,  Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica., 2021, vol 106, n°3, 701-707 p. Réf. HAL: inserm-02552097

Equipe 09 « Chromatin and Transcriptional Deregulation in Pediatric Bone Sarcoma »

Equipe 10 « Plasticity of Ecosystem from the Tumor after Radiotherapy »

Alzial G., Renoult O., Paris F., Gratas C., Clavreul A., Pecqueur C.,  Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma. Oncogene., 2021, Online ahead of print. Réf. HAL: inserm-03434277

Bahri M., Kailayangiri S., Vermeulen S., Galopin N., Rossig C., Paris F., Fougeray S., Birklé S.,  SIRPα-specific monoclonal antibody enables antibody-dependent phagocytosis of neuroblastoma cells. Cancer Immunology, Immunotherapy., 2021, Online ahead of print. Réf. HAL: inserm-03240786

Dusserre N., Stachowicz M.L., Medina C., Henri B., Fricain J.C., Paris F., Oliveira H.,  Microvalve bioprinting as a biofabrication tool to decipher tumor and endothelial cell crosstalk: Application to a simplified glioblastoma model. Bioprinting ., 2021, vol 24, e00178. Réf. HAL: inserm-03428127

Ollivier L., Labbé M., Fradin D., Potiron V., Supiot S.,  Interaction Between Modern Radiotherapy and Immunotherapy for Metastatic Prostate Cancer. Frontiers in Oncology., 2021, vol 11, 744679 p. Réf. HAL: inserm-03369787

Prasanna P., Citrin D., Hildesheim J., Ahmed M., Venkatachalam S., Riscuta G., Xi D., Zheng G., Deursen J.V., Goronzy J., Kron S., Anscher M., Sharpless N., Campisi J., Brown S., Niedernhofer L., O’loghlen A., Georgakilas A., Paris F., Gius D., Gewirtz D., Schmitt C., Abazeed M., Kirkland J., Richmond A., Romesser P., Lowe S., Gil J., Mendonca M., Burma S., Zhou D., Coleman C.N.,  Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy. JNCI: Journal of the National Cancer Institute., 2021, vol 113, n°10, 1285-1298 p. Réf. HAL: inserm-03547029

Sosa-Marrero C., De Crevoisier R., Hernandez A., Fontaine P., Rioux-Leclercq N., Mathieu R., Fautrel A., Paris F., Acosta O.,  Towards a reduced in silico model predicting biochemical recurrence after radiotherapy in prostate cancer. IEEE Transactions on Biomedical Engineering., 2021, vol 68, n°9, 2718-2729 p. Réf. HAL: inserm-03137032

Thomas P., Galopin N., Bonérandi E., Clémenceau B., Fougeray S., Birklé S.,  CAR T Cell Therapy’s Potential for Pediatric Brain Tumors. Cancers., 2021, vol 13, n°21, 5445 p. Réf. HAL: inserm-03522558

Tilly G., Cadoux M., Alexandra G., Morille J., Wiertlewski S., Pecqueur C., Brouard S., Laplaud D. A, Degauque N.,  Teriflunomide Treatment of Multiple Sclerosis Selectively Modulates CD8 Memory T Cells. Frontiers in Immunology., 2021, vol 12, 730342 p. Réf. HAL: inserm-03366173

Equipe 11 « Molecular Vulnerabilities of Tumor Escape in mature B-cell Malignancies »

Beauvais D., Bachy E., Baruchel A., Bay J.O., Caillot D., Cartron G., Damaj G., Furst S., Le Gouill S., Morschhauser F., Rabian F., Rubio M.T., Thieblemont C., Yakoub-Agha I.,  Éligibilité des patients aux cellules CAR-T : avis d’experts proposé par la SFGM-TC. Bulletin du Cancer., 2021, vol 108, n°7-8, 725-729 p. Réf. HAL: inserm-03349011

Camuset M., Huault A., Grain A., Clémenceau B., Rialland F., Thomas C., Chevallier P., Béné M., Eveillard M.,  Therapeutic targets in childhood B‐acute lymphoblastic leukemia: what about HER2/neu? Hematological Oncology., 2021, vol 39, n°2, 270-272 p. Réf. HAL: inserm-03500305

Chalopin T., Vallet N., Theisen O., Ochmann M., Tiab M., Godmer P., Barin C., Hérault O., Gyan E., Le Gouill S., Avet‐loiseau H., Benboubker L., Moreau P., Touzeau C.,  No survival improvement in patients with high‐risk multiple myeloma harbouring del(17p) and/or t(4;14) over the two past decades. British Journal of Haematology., 2021, vol 194, n°3, 635-638 p. Réf. HAL: inserm-03349139

Chiron D.,  Commentary on Rodrigues et al : Towards ecosystem integration for a better understanding of B-cell lymphomas aggressiveness. British Journal of Haematology., 2021,. Réf. HAL: inserm-03128392

Cohen J., Shah N., Alencar A., Gerson J., Patel M., Fahkri B., Jurczak W., Tan X., Lewis K., Fenske T., Coombs C., Flinn I., Lewis D., Le Gouill S., Palomba M.L., Woyach J., Pagel J., Lamanna N., Barve M., Ghia P., Eyre T., Yin M., Nair B., Tsai D., Ku N., Mato A., Cheah C., Wang M.,  ABCL-040: Pirtobrutinib (LOXO-305), a Next-Generation, Highly Selective, Non-Covalent Bruton’s Tyrosine Kinase Inhibitor in Previously Treated Mantle Cell Lymphoma and Other Non-Hodgkin Lymphomas: Phase 1/2 BRUIN Study Results. Clinical Lymphoma, Myeloma & Leukemia., 2021, vol 21, S378-S379. Réf. HAL: inserm-03546766

Ghesquières H., Dalban C., Nicolas‐virelizier E., Jardin F., Le Bras F., Le Gouill S., Casasnovas O., Vizoso S., Hernandez C., Metzger S., Pérol D., Cartron G.,  BeEAM (bendamustine, etoposide, cytarabine, melphalan) prior to autologous stem cell transplant for chemosensitive relapses in patients with follicular lymphoma: a prospective multicentre phase II study in Lymphoma Study Association centres. British Journal of Haematology., 2021, vol 192, n°3, e94-e98. Réf. HAL: inserm-03349131

Inam S., Ross J., Touzeau C., Moreau P., Kumar S., Harrison S.,  Paving the way to precision medicine in multiple myeloma. Expert Review of Hematology., 2021, vol 14, n°4, 323-327 p. Réf. HAL: inserm-03349126

Jullien M., Orvain C., Berceanu A., Couturier M.A., Guillaume T., Peterlin P., Garnier A., Bourgeois A. Le, Klemencie M., Schmidt A., Hunault M., Daguindau E., Roussel X., Delepine P., Guillerm G., Giltat A., François S., Thepot S., Gouill S. Le, Béné M.C., Chevallier P.,  Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis. Transplantation and Cellular Therapy., 2021, vol 27, n°10, 861.e1 – 861.e7 p. Réf. HAL: inserm-03436123

Jullien M., Tessoulin B., Ghesquières H., Oberic L., Morschhauser F., Tilly H., Ribrag V., Lamy T., Thieblemont C., Villemagne B., Gressin R., Bouabdallah K., Haioun C., Damaj G., Fornecker L.M., Schiano De Colella J.M., Feugier P., Hermine O., Cartron G., Bonnet C., André M., Bailly C., Casasnovas R.O., Le Gouill S.,  Deep-Learning Assessed Muscular Hypodensity Independently Predicts Mortality in DLBCL Patients Younger Than 60 Years. Cancers., 2021, vol 13, n°18, 4503 p. Réf. HAL: inserm-03540506

Jullien M., Touzeau C., Moreau P.,  Monoclonal antibodies as an addition to current myeloma therapy strategies. Expert Review of Anticancer Therapy., 2021, vol 21, n°1, 33-43 p. Réf. HAL: inserm-03498459

Laurent V., Fronteau C., Antier C., Dupuis P., Tessoulin B., Gastinne T., Mahé B., Blin N., Dubruille V., Lok A., Chevallier P., Guillaume T., Garnier A., Peterlin P., Le Bourgeois A., Vantyghem S., Tiab M., Godmer P., Sadot S., Loirat M., Trebouet A., Cormier N., Le Gouill S., Moreau P., Touzeau C.,  Autologous stem-cell collection following VTD or VRD induction therapy in multiple myeloma: a single-center experience. Bone Marrow Transplantation., 2021, vol 56, n°2, 395-399 p. Réf. HAL: inserm-03495985

Le Calvez B., Moreau P., Touzeau C.,  Immune checkpoint inhibitors for the treatment of myeloma: novel investigational options. Expert Opinion on Investigational Drugs., 2021, vol 30, n°9, 965-973 p. Réf. HAL: inserm-03349119

Le Gallou S., Lhomme F., Irish J.M., Mingam A., Pangault C., Monvoisin C., Ferrant J., Azzaoui I., Rossille D., Bouabdallah K., Damaj G., Cartron G., Godmer P., Le Gouill S., Casasnovas R.O., Molina T.J., Houot R., Lamy T., Tarte K., Fest T., Roussel M.,  Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma. Frontiers in Immunology., 2021, vol 12, 755623 p. Réf. HAL: hal-03531047

Le Gouill S., Ghesquieres H., Obéric L., Morschhauser F., Tilly H., Ribrag V., Lamy T., Thieblemont C., Maisonneuve H.G., Gressin R., Bouabdallah K., Haioun C., Damaj G., Fornecker L.M., Bouabdallah R., Feugier P., Sibon D., Cartron G., Bonnet C., André M., Chartier L., Ruminy P., Kraeber-Bodere F., Bodet-Milin C., Berriolo-Riedinger A., Briere J., Jais J.P., Molina T., Itti E., Casasnovas O.,  Obinutuzumab versus Rituximab in young patients with advanced DLBCL, a PET-guided and randomized phase 3 study by LYSA. Blood., 2021, vol 137, n°17, 2307-2320 p. Réf. HAL: hal-03122586

Mato A. R, Shah N. N, Jurczak W., Cheah C. Y, Pagel J. M, Woyach J. A, Fakhri B., Eyre T. A, Lamanna N., Patel M. R, Alencar A., Lech-Maranda E., Wierda W. G, Coombs C. C, Gerson J. N, Ghia P., Le Gouill S., Lewis D. John, Sundaram S., Cohen J. B, Flinn I. W, Tam C. S, Barve M. A, Kuss B., Taylor J., Abdel-Wahab O., Schuster S. J, Palomba L., Lewis K. L, Roeker L. E, Davids M. S, Tan X. Ni, Fenske T. S, Wallin J., Tsai D. E, Ku N. C, Zhu E., Chen J., Yin M., Nair B., Ebata K., Marella N., Brown J. R, Wang M.,  Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study. The Lancet., 2021, vol 397, n°10277, 892-901 p. Réf. HAL: inserm-03349042

Peterlin P., Gaschet J., Guillaume T., Garnier A., Eveillard M., Le Bourgeois A., Cherel M., Debord C., Le Bris Y., Theisen O., Godon C., Mahé B., Dubruille V., Wuilleme S., Touzeau C., Gastinne T., Blin N., Lok A., Tessoulin B., Le Gouill S., Moreau P., Béné M., Chevallier P.,  A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Medicine., 2021, vol 10, n°2, 642-648 p. Réf. HAL: inserm-03495750

Richardson P. G, Oriol A., Larocca A., Bladé J., Cavo M., Rodriguez-Otero P., Leleu X., Nadeem O., Hiemenz J. W, Hassoun H., Touzeau C., Alegre A., Paner A., Maisel C., Mazumder A., Raptis A., Moreb J. S, Anderson K. C, Laubach J. P, Thuresson S., Thuresson M., Byrne C., Harmenberg J., Bakker N. A, Mateos V.,  Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma. Journal of Clinical Oncology., 2021, vol 39, n°7, 757-767 p. Réf. HAL: inserm-03349153

Rodríguez-Otero P., Mateos M.V., Oriol A., Larocca A., Blade J., Cavo M., Leleu X., Nadeem O., Hiemenz J., Hassoun H., Touzeau C., Alegre A., Paner A., Maisel C., Mazumder A., Raptis A., Thuresson M., Harmenberg J., Harlin O., Richardson P.,  Melflufen plus dexamethasone (dex) in patients (pts) with relapsed/refractory multiple myeloma (RRMM) exposed/refractory to prior alkylators: A pooled analysis of the O-12-M1 and HORIZON studies. Journal of Clinical Oncology., 2021, vol 39, n°15_suppl, 8048-8048 p. Réf. HAL: inserm-03546678

Tessoulin B., Chiron D., Thieblemont C., Oberic L., Bouadballah K., Gyan E., Damaj G., Ribrag V., Gressin R., Feugier P., Casasnovas O., Zerazhi H., Lemonnier F., Maisonneuve H., Joubert C., Van Den Neste E., Lamy T., Tilly H., Moreau A., Hermine O., Le Gouill S.,  Oxaliplatin before autologous transplantation in combination with high-dose cytarabine and rituximab provides longer disease control than cisplatin or carboplatin in patients with mantle-cell lymphoma: results from the LyMA prospective trial. Bone Marrow Transplantation., 2021, vol 56, n°7, 1700-1709 p. Réf. HAL: hal-03203334

Touzeau C., Antier C., Moreau P.,  Carfilzomib in combination with daratumumab in the management of relapsed multiple myeloma. Future Oncology., 2021, vol 17, n°9, 993-998 p. Réf. HAL: inserm-03496299

Touzeau C., Quignot N., Meng J., Jiang H., Khachatryan A., Singh M., Taieb V., Chauny J.V., Désaméricq G.,  Survival and treatment patterns of patients with relapsed or refractory multiple myeloma in France — a cohort study using the French National Healthcare database (SNDS). Annals of Hematology., 2021, vol 100, n°7, 1825-1836 p. Réf. HAL: inserm-03349226

Vantyghem S., Peterlin P., Thépot S., Ménard A., Dubruille V., Debord C., Guillaume T., Garnier A., Le Bourgeois A., Wuilleme S., Godon C., Theisen O., Eveillard M., Delaunay J., Maisonneuve H., Morineau N., Villemagne B., Vigouroux S., Subiger F., Lestang E., Loirat M., Parcelier A., Godmer P., Mercier M., Trebouet A., Paz D. Luque, Le Calloch R., Le Clech L., Bossard C., Moreau A., Ugo V., Hunault M., Moreau P., Le Gouill S., Chevallier P., Béné M. C, Le Bris Y.,  Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica., 2021, vol 106, n°3, 701-707 p. Réf. HAL: inserm-02552097

Equipe 12 « Manipulation of Lymphocytes for Immunotherapy »

Aguilar E., Dunai C., J Judge S., Elston Zamora A., T Khuat L., V Vick L., P Collins C., M Stoffel K., Alvarez M., Barao I., S Miller J., Blazar B.R., Chevallier P., Retiere C., J Canter R., J Murphy W.,  Activation Status Dictates the Function of Unlicensed Natural Killer Cells. Blood Advances., 2021, bloodadvances.2021004589. Réf. HAL: inserm-03346742

Bechara R., Chevalier M., Gautreau-Rolland L., Nabhan M., Simon S., Mossadegh-Keller N.,  French club of Young Immunologists: One year and counting. European Journal of Immunology., 2021, vol 51, n°9, 2351-2351 p. Réf. HAL: inserm-03540894

Béné M.,  Issue Highlights—September 2021. Cytometry Part B: Clinical Cytometry., 2021, vol 100, n°5, 537-540 p. Réf. HAL: inserm-03546649

Béné M. C, Lacombe F., Porwit A.,  Unsupervised flow cytometry analysis in hematological malignancies: A new paradigm. International Journal of Laboratory Hematology., 2021, vol 43, n°1, 54-64 p. Réf. HAL: inserm-03365100

Camuset M., Huault A., Grain A., Clémenceau B., Rialland F., Thomas C., Chevallier P., Béné M., Eveillard M.,  Therapeutic targets in childhood B‐acute lymphoblastic leukemia: what about HER2/neu? Hematological Oncology., 2021, vol 39, n°2, 270-272 p. Réf. HAL: inserm-03500305

Cano C., Pasero C., De Gassart A., Kerneur C., Gabriac M., Fullana M., Granarolo E., Hoet R., Scotet E., Rafia C., Herrmann T., Imbert C., Gorvel L., Vey N., Briantais A., Le Floch A.C., Olive D.,  BTN2A1, an immune checkpoint targeting Vγ9Vδ2 T cell cytotoxicity against malignant cells. Cell Reports., 2021, vol 36, n°2, 109359 p. Réf. HAL: inserm-03547155

Capitao M., Perrin J., Simon S., Gouard S., Chouin N., Bruchertseifer F., Morgenstern A., Rbah-Vidal L., Chérel M., Scotet E., Labarrière N., Guilloux Y., Gaschet J.,  Anti-Tumor Efficacy of PD-L1 Targeted Alpha-Particle Therapy in a Human Melanoma Xenograft Model. Cancers., 2021, vol 13, n°6, 1256 p. Réf. HAL: inserm-03171640

Chevallier P., Saiagh S., Dehame V., Guillaume T., Peterlin P., Bercegeay S., Le Bris Y., Bossard C., Gauvrit I., Dreno B., Juge-Morineau N., Béné M. C, Gregoire M.,  A phase I/II feasibility vaccine study by autologous leukemic apoptotic corpse-pulsed dendritic cells for elderly AML patients. Human Vaccines & Immunotherapeutics., 2021, Online ahead of print. Réf. HAL: inserm-03335625

David G., Willem C., Legrand N., Djaoud Z., Mérieau P., Walencik A., Guillaume T., Gagne K., Chevallier P., Retiere C.,  Deciphering the biology of KIR2DL3+ T lymphocytes that are associated to relapse in haploidentical HSCT. Scientific Reports., 2021, vol 11, n°1, 15782 p. Réf. HAL: inserm-03317982

De Gassart A., Le K.S., Brune P., Agaugué S., Sims J., Goubard A., Castellano R., Joalland N., Scotet E., Collette Y., Valentin E., Ghigo C., Pasero C., Colazet M., Guillén J., Cano C., Marabelle A., De Bonno J., Hoet R., Truneh A., Olive D., Frohna P.,  Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell–mediated antitumor immune response. Science Translational Medicine., 2021,. Réf. HAL: inserm-03540734

Dubreuil L., Chevallier P., Retiere C., Gagne K.,  Relevance of Polymorphic KIR and HLA Class I Genes in NK-Cell-Based Immunotherapies for Adult Leukemic Patients. Cancers., 2021, vol 13, n°15, 3767 p. Réf. HAL: inserm-03317983

Esnault C., Leblond V., Martin C., Desgranges A., Baltus C., Aubrey N., Lakhrif Z., Lajoie L., Lantier L., Clémenceau B., Sarma B., Schrama J., Houben R., Schrama D., Hesbacher S., Gouilleux-Gruart V., Feng Y., Dimitrov D., Guyétant S., Berthon P., Viaud‐massuard M., Samimi M., Touzé A., Kervarrec T.,  Adcitmer ®, a new CD56‐targeting monomethyl auristatin E‐conjugated antibody, is a potential therapeutic approach in Merkel cell carcinoma. British Journal of Dermatology., 2021,. Réf. HAL: hal-03469322

Fahl S., Contreras A., Verma A., Qiu X., Harly C., Radtke F., Zúñiga-Pflücker J.C., Murre C., Xue H.H., Sen J.M., Wiest D.,  The E protein-TCF1 axis controls γδ T cell development and effector fate. Cell Reports., 2021, vol 34, n°5, 108716 p. Réf. HAL: inserm-03538823

Gastinne T., Le Bourgeois A., Coste‐burel M., Guillaume T., Peterlin P., Garnier A., Imbert B., Drumel T., Mahe B., Dubruille V., Blin N., Lok A., Touzeau C., Tessoulin B., Jullien M., Vanthygem S., Béné M. C, Moreau P., Le Gouill S., Chevallier P.,  Safety and antibody response after one and/or two doses of BNT162b2 Anti‐SARS‐CoV‐2 mRNA vaccine in patients treated by CAR T cells therapy. British Journal of Haematology., 2021, Online ahead of print. Réf. HAL: inserm-03388040

Hedou E., Douceau S., Chevilley A., Varangot A., Thiebaut A., Triniac H., Bardou I., Ali C., Maillasson M., Crepaldi T., Comoglio P., Lemarchand E., Agin V., Roussel B. D, Vivien D.,  Two-Chains Tissue Plasminogen Activator Unifies Met and NMDA Receptor Signalling to Control Neuronal Survival. International Journal of Molecular Sciences., 2021, vol 22, n°24, 13483 p. Réf. HAL: inserm-03547069

Johnnidis J. B, Muroyama Y., Foong Ngiow S., Chen Z., Manne S., Cai Z., Song S., Platt J. M, Schenkel J. M, Abdel-Hakeem M., Beltra J.C., Greenplate A. R, Ali M.A. A, Nzingha K., Giles J. R, Harly C., Attanasio J., Pauken K. E, Bengsch B., Paley M. A, Tomov V. T, Kurachi M., Vignali D. A A, Sharpe A. H, Reiner S. L, Bhandoola A., Johnson F. Bradley, Wherry E. John,  Inhibitory signaling sustains a distinct early memory CD8 + T cell precursor that is resistant to DNA damage. Science Immunology., 2021, vol 6, eabe3702. Réf. HAL: inserm-03276330

Jullien M., Orvain C., Berceanu A., Couturier M.A., Guillaume T., Peterlin P., Garnier A., Bourgeois A. Le, Klemencie M., Schmidt A., Hunault M., Daguindau E., Roussel X., Delepine P., Guillerm G., Giltat A., François S., Thepot S., Gouill S. Le, Béné M.C., Chevallier P.,  Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis. Transplantation and Cellular Therapy., 2021, vol 27, n°10, 861.e1 – 861.e7 p. Réf. HAL: inserm-03436123

Latypova X., Vincent M., Mollé A., Adebambo O. A, Fourgeux C., Khan T. N, Caro A., Rosello M., Orellana C., Niyazov D., Lederer D., Deprez M., Capri Y., Kannu P., Tabet A. Claude, Levy J., Aten E., Den Hollander N., Splitt M., Walia J., Immken L. L, Stankiewicz P., Mcwalter K., Suchy S., Louie R. J, Bell S., Stevenson R. E, Rousseau J., Willem C., Retiere C., Yang X.J., Campeau P. M, Martinez F., Rosenfeld J. A, Le Caignec C., Küry S., Mercier S., Moradkhani K., Conrad S., Besnard T., Cogné B., Katsanis N., Bézieau S., Poschmann J., Davis E. E, Isidor B.,  Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder. American Journal of Human Genetics., 2021, vol 108, n°5, 929 – 941 p. Réf. HAL: inserm-03290535

Le Bourgeois A., Coste‐burel M., Guillaume T., Peterlin P., Garnier A., Imbert B., Drumel T., Mahé B., Dubruille V., Blin N., Lok A., Touzeau C., Gastinne T., Tessoulin B., Jullien M., Vantyghem S., Moreau P., Le Gouill S., Béné M., Chevallier P.,  Interest of a third dose of BNT162b2 anti‐SARS‐CoV‐2 messenger RNA vaccine after allotransplant. British Journal of Haematology., 2021, 10.1111/bjh.17911 p. Réf. HAL: inserm-03542571

Legrand N., David G., Rodallec A., Gaultier A., Salmon D., Cesbron A., Wittkop L., Raffi F., Gendzekhadze K., Retière C., Allavena C., Gagne K.,  Influence of HLA‐C environment on the spontaneous clearance of hepatitis C in European HIV–HCV co‐infected individuals. Clinical and Experimental Immunology., 2021, Online ahead of print. Réf. HAL: inserm-03136993

Lejeune M., Duray E., Peipp M., Clémenceau B., Baron F., Beguin Y., Caers J.,  Balancing the CD38 Expression on Effector and Target Cells in Daratumumab-Mediated NK Cell ADCC against Multiple Myeloma. Cancers., 2021, vol 13, n°12, 3072 p. Réf. HAL: inserm-03290143

Ljungman P., Bermudez A., Logan A. C, Kharfan-Dabaja M. A, Chevallier P., Martino R., Wulf G., Selleslag D., Kakihana K., Langston A., Lee D.G., Solano C., Okamoto S., Smith L. R, Boeckh M., Wingard J. R, Cywin B., Fredericks C., Lademacher C., Wang X., Young J., Maertens J.,  A randomised, placebo-controlled phase 3 study to evaluate the efficacy and safety of ASP0113, a DNA-based CMV vaccine, in seropositive allogeneic haematopoietic cell transplant recipients. EClinicalMedicine., 2021, vol 33, 100787 p. Réf. HAL: inserm-03532634

Loosdrecht A., Kern W., Porwit A., Valent P., Kordasti S., Cremers E., Alhan C., Duetz C., Dunlop A., Hobo W., Preijers F., Wagner‐ballon O., Chapuis N., Fontenay M., Bettelheim P., Eidenschink‐brodersen L., Font P., Johansson U., Loken M., Marvelde J., Matarraz S., Ogata K., Oelschlaegel U., Orfao A., Psarra K., Subirá D., Wells D., Béné M., Della Porta M., Burbury K., Bellos F., Velden V., Westers T., Saft L., Ireland R.,  Clinical application of flow cytometry in patients with unexplained cytopenia and suspected myelodysplastic syndrome: A report of the European LeukemiaNet International MDS‐Flow Cytometry Working Group. Cytometry Part B: Clinical Cytometry., 2021, Online ahead of print. Réf. HAL: inserm-03540442

Makanga D. Roméo, Jullien M., David G., Legrand N., Willem C., Dubreuil L., Walencik A., Touzeau C., Gastinne T., Tessoulin B., Le Gouill S., Mahé B., Gagne K., Chevallier P., Clemenceau B., Retière C.,  Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell response. OncoImmunology., 2021, vol 10, n°1, 1936392 p. Réf. HAL: inserm-03287975

Marotte L., Capitao M., Deleine C., Beauvais T., Cadiou G., Perrin J., Chérel M., Scotet E., Guilloux Y., Bruchertseifer F., Morgenstern A., Jarry A., Gaschet J., Labarrière N.,  Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes. OncoImmunology., 2021, vol 10, n°1, e1940676. Réf. HAL: inserm-03271847

Moradi S., Stankovic S., O’connor G. M, Pymm P., Maclachlan B. J, Faoro C., Retiere C., Sullivan L. C, Saunders P. M, Widjaja J., Cox-Livingstone S., Rossjohn J., Brooks A. G, Vivian J. P,  Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nature Communications., 2021, vol 12, n°1, 2173 p. Réf. HAL: inserm-03290537

Peterlin P., Chevallier P., Knapper S., Collin M.,  FLT3 ligand in acute myeloid leukemia: a simple test with deep implications. Leukemia & lymphoma., 2021, vol 62, n°2, 264-270 p. Réf. HAL: inserm-03496910

Peterlin P., Gaschet J., Guillaume T., Garnier A., Eveillard M., Le Bourgeois A., Cherel M., Debord C., Le Bris Y., Theisen O., Godon C., Mahé B., Dubruille V., Wuilleme S., Touzeau C., Gastinne T., Blin N., Lok A., Tessoulin B., Le Gouill S., Moreau P., Béné M., Chevallier P.,  A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia. Cancer Medicine., 2021, vol 10, n°2, 642-648 p. Réf. HAL: inserm-03495750

Smadja J., Quéméner A., Maillasson M., Sicard B., Leray A., Arzel L., Lebreton J., Mortier E., Dubreuil D., Mathé-Allainmat M.,  Rational modification, synthesis and biological evaluation of N-substituted phthalazinone derivatives designed to target interleukine-15 protein. Bioorganic & Medicinal Chemistry Letters., 2021, vol 39, 116161 p. Réf. HAL: inserm-03214947

Thiebaut A. M, Buendia I., Ginet V., Lemarchand E., Boudjadja M.B., Hommet Y., Lebouvier L., Lechevallier C., Maillasson M., Hedou E., Déglon N., Oury F., Rubio M., Montaner J., Puyal J., Vivien D., Roussel B. D,  Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia. Autophagy., 2021, Online ahead of print. Réf. HAL: inserm-03353631

Thomas P., Galopin N., Bonérandi E., Clémenceau B., Fougeray S., Birklé S.,  CAR T Cell Therapy’s Potential for Pediatric Brain Tumors. Cancers., 2021, vol 13, n°21, 5445 p. Réf. HAL: inserm-03522558

Vanhove B., Duvaux O., Rousse J., Royer P., Evanno G., Ciron C., Lheriteau E., Vacher L., Gervois N., Oger R., Jacques Y., Conchon S., Salama A., Duchi R., Lagutina I., Perota A., Delahaut P., Ledure M., Paulus M., So R. T, Mok C. Ka‐pun, Bruzzone R., Bouillet M., Brouard S., Cozzi E., Galli C., Blanchard D., Bach J., Soulillou J.,  High neutralizing potency of swine glyco‐humanized polyclonal antibodies against SARS‐CoV‐2. European Journal of Immunology., 2021, vol 51, n°6, 1412 – 1422 p. Réf. HAL: inserm-03333751

Vantyghem S., Peterlin P., Thépot S., Ménard A., Dubruille V., Debord C., Guillaume T., Garnier A., Le Bourgeois A., Wuilleme S., Godon C., Theisen O., Eveillard M., Delaunay J., Maisonneuve H., Morineau N., Villemagne B., Vigouroux S., Subiger F., Lestang E., Loirat M., Parcelier A., Godmer P., Mercier M., Trebouet A., Paz D. Luque, Le Calloch R., Le Clech L., Bossard C., Moreau A., Ugo V., Hunault M., Moreau P., Le Gouill S., Chevallier P., Béné M. C, Le Bris Y.,  Diagnosis and prognosis are comforted by integrated assessment of next-generation sequencing in chronic myeloid malignancies. A real-life study. Haematologica., 2021, vol 106, n°3, 701-707 p. Réf. HAL: inserm-02552097

Velden V., Preijers F., Johansson U., Westers T., Dunlop A., Porwit A., Béné M., Valent P., Marvelde J., Wagner‐ballon O., Oelschlaegel U., Saft L., Kordasti S., Ireland R., Cremers E., Alhan C., Duetz C., Hobo W., Chapuis N., Fontenay M., Bettelheim P., Eidenshink‐brodersen L., Font P., Loken M., Matarraz S., Ogata K., Orfao A., Psarra K., Subirá D., Wells D., Della Porta M., Burbury K., Bellos F., Weiß E., Kern W., Loosdrecht A.,  Flow cytometric analysis of myelodysplasia: Pre‐analytical and technical issues—Recommendations from the European LeukemiaNet. Cytometry Part B: Clinical Cytometry., 2021, Online ahead of print. Réf. HAL: inserm-03540872

2O2O

Equipe 01 « Immunomodulation of the tumor microenvironment and immunotherapy of thoracic cancers »

Blanquart C., Jaurand M.C., Jean D., The Biology of Malignant Mesothelioma and the Relevance of Preclinical Models. Frontiers in Oncology., 2020, vol 10, Epub ahead of print. Réf. HAL: inserm-02518612

Blondy T., Mickael D’almeida S., Briolay T., Tabiasco J., Meiller C., Chéné A.L., Cellerin L., Deshayes S., Delneste Y., Fonteneau J.F., Boisgerault N., Bennouna J., Grégoire M., Jean D., Blanquart C., Involvement of the M-CSF/IL-34/CSF- 1R pathway in malignant pleural mesothelioma. Journal for Immunotherapy of Cancer., 2020, vol 8, n°1, e000182. Réf. HAL: inserm-02913733

Coupez D., Hulo P., Touchefeu Y., Bossard C., Bennouna J., Pembrolizumab for the treatment of colorectal cancer. Expert Opinion on Biological Therapy., 2020, vol 20, n°3, 219-226 p. Réf. HAL: inserm-02547539

Delaunay T., Achard C., Boisgerault N., Grard M., Petithomme T., Chatelain C., Dutoit S., Blanquart C., Royer P.J., Minvielle S., Quetel L., Meiller C., Jean D., Fradin D., Bennouna J., Magnan A., Cellerin L., Tangy F., Grégoire M., Fonteneau J.F., Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus : Interferon genes loss sensitizes tumor cells to viral lysis. Journal of Thoracic Oncology., 2020, vol S1556-0864(20)30019-8, Epub ahead of print. Réf. HAL: inserm-02447160

Delaunay T., Achard C., Gregoire M., Tangy F., Boisgerault N., Fonteneau J.F., A Functional Assay to Determine the Capacity of Oncolytic Viruses to Induce Immunogenic Tumor Cell Death. Methods in Molecular Biology., 2020, vol 2058, 127-132 p. Réf. HAL: inserm-02285959

Delaunay T., Nader J., Grard M., Farine I., Hedwig V., Foloppe J., Blondy T., Violland M., Pouliquen D. L., Grégoire M., Boisgerault N., Erbs P., Fonteneau J.F., High oncolytic activity of a double deleted Vaccinia Virus Copenhagen strain against malignant pleural mesothelioma : Mesothelioma and oncolytic vaccinia virus. Molecular Therapy – Oncolytics., 2020, Online ahead of print. Réf. HAL: inserm-02913764

Denis M., Bennouna J., Osimertinib for Front-Line Treatment of Locally Advanced or Metastatic EGFR -Mutant NSCLC Patients: Efficacy, Acquired Resistance and Perspectives for Subsequent Treatments. Cancer Management and Research., 2020, vol Volume 12, 12593-12602 p. Réf. HAL: inserm-03498514

Gauttier V., Pengam S., Durand J., Biteau K., Mary C., Morello A., Néel M., Porto G., Teppaz G., Thepenier V., Danger R., Vince N., Wilhelm E., Girault I., Abes R., Ruiz C., Trilleaud C., Ralph K., Trombetta E.S., Garcia A., Vignard V., Martinet B., Glemain A., Bruneau S., Haspot F., Dehmani S., Duplouye P., Miyasaka M., Labarrière N., Laplaud D., Le Bas-Bernardet S., Blanquart C., Catros V., Gouraud P.A., Archambeaud I., Aublé H., Métairie S., Mosnier J.F., Costantini D., Blancho G., Conchon S., Vanhove B., Poirier N., Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. Journal of Clinical Investigation., 2020, vol 130, n°11, 6109-6123 p. Réf. HAL: hal-03001660

Hulo P., Coupez D., Denis M., Bennouna J., EGFR mutation-positive NSCLC: factors to consider when deciding first-line therapy. Expert Review of Anticancer Therapy., 2020, vol 20, n°5, 365-372 p. Réf. HAL: inserm-03496565

Hulo P., Touchefeu Y., Cauchin E., Archambeaud I., Chapelle N., Bossard C., Bennouna J., Acute Ulceronecrotic Gastritis With Cytomegalovirus Reactivation: Uncommon Toxicity of Immune Checkpoint Inhibitors in Microsatellite Instability–High Metastatic Colorectal Cancer. Clinical Colorectal Cancer., 2020, vol 19, e183 – e188. Réf. HAL: hal-03493530

Jean D., Delaunay T., Meiller C., Boisgerault N., Grard M., Caruso S., Blanquart C., Felley-Bosco E., Bennouna J., Tangy F., Grégoire M., Fonteneau J.F., Reply to: Oncolytic Viral Therapy for Malignant Pleural Mesothelioma. Journal of Thoracic Oncology., 2020,. Réf. HAL: inserm-02547453

Kara-Terki L., Treps L., Blanquart C., Fradin D., Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers. International Journal of Molecular Sciences., 2020, vol 21, n°17, 6024 p. Réf. HAL: inserm-02946311

Labbé M., Hoey C., Ray J., Potiron V., Supiot S., Liu S. K, Fradin D., microRNAs identified in prostate cancer: Correlative studies on response to ionizing radiation. Molecular Cancer., 2020, vol 19, 63 p. Réf. HAL: inserm-02515300

Nader J. S, Boissard A., Henry C., Valo I., Verrièle V., Grégoire M., Coqueret O., Guette C., Pouliquen D. L, Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma. Cancers., 2020,. Réf. HAL: inserm-02945810

Nader J. L, Guillon J., Petit C., Boissard A., Franconi F., Blandin S., Lambot S., Gregoire M., Verriele V., Nawrocki-Raby B., Birembaut P., Coqueret O., Guette C., Pouliquen D. L., S100A4 Is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma. Cancers., 2020, vol 12, n°4, E939. Réf. HAL: inserm-02546002

Parrot T., Oger R., Allard M., Desfrançois J., Raingeard De La Blétìère D., Coutolleau A., Preisser L., Khammari A., Dréno B., Delneste Y., Guardiola P., Fradin D., Gervois N., Transcriptomic features of tumour- infiltrating CD4 low CD8 high double positive αβ T cells in melanoma. Scientific Reports., 2020, vol 10, n°1, 5900 p. Réf. HAL: inserm-02534481

Petithomme T., Grard M., Fonteneau J.F., Boisgerault N., Le vaccin contre la fièvre jaune comme nouveau traitement antitumoral ? : [The yellow fever vaccine as a new cancer treatment?]. médecine/sciences., 2020, vol 36, n°12, 1216-1217 p. Réf. HAL: inserm-03094010

Soamalala J., Diot S., Pellerano M., Blanquart C., Galibert M., Jullian M., Puget K., Morris M., Fluorescent peptide biosensor for probing CDK6 activity in lung cancer cell extracts. ChemBioChem., 2020, Online ahead of print. Réf. HAL: inserm-03006777

Vallion R., Divoux J., Glauzy S., Ronin E., Lombardi Y., Lubrano Di Ricco M., Grégoire S., Nemazanyy I., Durand A., Fradin D., Lucas B., Salomon B., Regulatory T Cell Stability and Migration Are Dependent on mTOR. Journal of Immunology., 2020, vol 205, n°7, 1799-1809 p. Réf. HAL: inserm-02946304

Hulo P., Deshayes S., Dehame V., Grégoire M., Bennouna J., Blanquart C., Impact of chemotherapy on lung cancer cells and their microenvironment, evaluated in tridimensional multicellular tumor spheroids, 2020, AACR Annual Meeting 2020, 27 avril 2020, Philadelphia (États-Unis). 319-319. Réf. HAL: inserm-03498348

Equipe 02 « Nuclear Oncology »

Ansquer C., Drui D., Mirallié E., Renaudin-Autain K., Denis A., Gimenez-Roqueplo A.P., Leux C., Toulgoat F., Kraeber-Bodéré F., Carlier T., Usefulness of FDG-PET/CT-Based Radiomics for the Characterization and Genetic Orientation of Pheochromocytomas Before Surgery. Cancers., 2020, vol 12, n°9, 2424 p. Réf. HAL: inserm-03006808

Bailly C., Carlier T., Berriolo-Riedinger A., Casasnovas O., Gyan E., Meignan M., Moreau A., Burroni B., Djaileb L., Gressin R., Devillers A., Lamy T., Thieblemont C., Hermine O., Kraeber-Bodéré F., Le Gouill S., Bodet-Milin C. M, Prognostic value of FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project. Haematologica., 2020, vol 104, n°1, e33-e36. Réf. HAL: inserm-02266351

Bailly C., Carlier T., Kraeber-Bodéré F., Le Gouill S., Bodet-Milin C., Prognostic value of F-18-FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project Reply. Haematologica., 2020, vol 105, n°1, e42-e42. Réf. HAL: inserm-03498726

Bailly C., Carlier T. M, Kraeber-Bodéré F., Le Gouill S. L, Bodet-Milin C., Reply to E. Laffon et al. Haematologica., 2020,. Réf. HAL: inserm-02908548

Bailly C., Chalopin B., Gouard S., Carlier T., Remaud-Le Saec P., Marionneau-Lambot S., Moreau P., Touzeau C., Kraeber-Bodéré F., Bodet-Milin C. M, Chérel M., ImmunoPET in Multiple Myeloma—What? So What? Now What? Cancers., 2020, vol 12, n°6, 1467 p. Réf. HAL: inserm-02881836

Barbet J. F, Bernaudin M., Payoux P., Cicone F., Gaugler M.H., Kraeber-Bodéré F., Editorial: Nuclear Medicine in the Context of Personalized Medicine. Frontiers in Medicine., 2020, vol 7, 252 p. Réf. HAL: inserm-02908566

Carlier T., Ferrer L., Conti M., Bodet-Milin C., Rousseau C., Bercier Y., Bendriem B., Kraeber-Bodéré F., From a PMT-based to a SiPM-based PET system: a study to define matched acquisition/reconstruction parameters and NEMA performance of the Biograph Vision 450. EJNMMI Physics., 2020, vol 7, n°1, 55 p. Réf. HAL: inserm-03006883

Da-Ano R., Masson I., Lucia F., Dore M., Robin P., Alfieri J., Wimart-Rousseau C., Mervoyer A., Reinhold C., Castelli J., De Crevoisier R., Rameé J.F., Pradier O., Schick U., Visvikis D., Hatt M., Performance comparison of modified ComBat for harmonization of radiomic features for multicenter studies. Scientific Reports., 2020, vol 10, n°1, 10248 p. Réf. HAL: hal-02887419

Delage J., Faivre-Chauvet A., Fierle J. K, Gnesin S., Schaefer N., Coukos G., Dunn S. M, Viertl D., Prior J. O, 177Lu radiolabeling and preclinical theranostic study of 1C1m-Fc: an anti-TEM- 1 scFv-Fc fusion protein in soft tissue sarcoma. EJNMMI Research., 2020, vol 10, n°1, 98 p. Réf. HAL: inserm-02923381

Etienne F., Berthaud M., Nguyen F., Bernardeau K., Maurel C., Bodet-Milin C., Diab M., Abadie J., Gouilleux-Gruart V., Vidal A., Bourgeois M., Chouin N., Ibisch C., Davodeau F., SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human. Frontiers in Oncology., 2020, vol 10, 20 p. Réf. HAL: inserm-02512859

Eychenne R., Bouvry C., Bourgeois M., Loyer P., Benoist E., Lepareur N., Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy. Molecules., 2020, vol 25, n°17, 4012 p. Réf. HAL: hal-02957763

Gil A.V., Amato E., Auditore L., Brenet M., Chauvin M., Clayton N., Ferrer L., Gibaud B., Gnesin S., Italiano A., Kayal G., Lima T., Ocampo J., Pistone D., Quan G., Mora Ramirez E., Ruegger J., Bardies M., OpenDose3D: A free, collaborative 3D Slicer module for patient-specific dosimetry. European Journal of Nuclear Medicine and Molecular Imaging., 2020, vol 47, n°SUPPL 1, S314-S315. Réf. HAL: hal-03095450

Gouard S., Saï-Maurel C., Marionneau-Lambot S., Dansette D., Bailly C., Guérard F., Chouin N., Haddad F., Alliot C., Gaschet J., Eychenne R., Kraeber-Bodéré F., Chérel M., Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease. Cancers., 2020, vol 12, n°9, 2721 p. Réf. HAL: inserm-03006927

Grégoire H., Roncali L., Rousseau A., Chérel M., Delneste Y., Hindré F., Garcion E., Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma. Frontiers., 2020, Epub ahead of print. Réf. HAL: inserm-02512928

Guérard F., Lee Y.S., Tripier R., Szajek L., Deschamps J., Brechbiel M., Reply to the ‘Comment on « Investigation of Zr(IV) and 89 Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging »‘ by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D. Chemical Communications., 2020, Online ahead of print. Réf. HAL: inserm-02947405

Jamet B., Bailly C., Carlier T., Touzeau C., Michaud A.V., Bourgeois M., Moreau P., Bodet-Milin C. M, Kraeber-Bodéré F., Imaging of Monoclonal Gammapathy of Undetermined Significance and Smoldering Multiple Myeloma. Cancers., 2020, vol 12, n°2, 486 p. Réf. HAL: inserm-02908721

Jamet B., Zamagni E., Nanni C., Bailly C., Carlier T., Touzeau C., Michaud A.V., Moreau P., Bodet-Milin C., Kraeber-Bodere F., Functional Imaging for Therapeutic Assessment and Minimal Residual Disease Detection in Multiple Myeloma. International Journal of Molecular Sciences., 2020, vol 21, n°15, 5406 p. Réf. HAL: inserm-03497317

Le Calvez B., Le Bris Y., Herbreteau G., Jamet B., Bossard C., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Antier C., Theisen O., Kraeber-Bodéré F., Le Gouill S., Béné M.C., Moreau P., Touzeau C., RASmutation leading to acquired resistance to dabrafenib and trametinib therapy in a multiplemyeloma patient harboring BRAF mutation. European Journal of Haematology., 2020, Online ahead of print. Réf. HAL: inserm-02874002

Le Thiec M., Testard A., Ferrer L., Guillerminet C., Morel O., Maucherat B., Rusu D., Girault S., Lacombe M., Hamidou H., Guérin Meyer V., Rio E., Hiret S., Kraeber-Bodéré F., Campion L., Rousseau C., Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer. Cancers., 2020, vol 12, n°6, 1512 p. Réf. HAL: inserm-02908736

Leonetti D., Estephan H., Ripoche N., Dubois N., Aguesse A., Gouard S., Brossard L., Chiavassa S., Corre I., Neunlist M., Hadchity E., Gaugler M.H., Mahé M., Paris F., Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation induced intestinal toxicity. Cancer Research., 2020,. Réf. HAL: inserm-02539662

Loussouarn A., Béhar G., Pecorari F., Croyal M., Renodon-Cornière A., Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering. Scientific Reports., 2020, vol 10, n°1, 1-13 p. Réf. HAL: inserm-03007124

Marotte L., Simon S., Vignard V., Dupré E., Gantier M., Cruard J., Alberge J.B., Hussong M., Deleine C., Heslan J.M., Shaffer J., Beauvais T., Gaschet J., Scotet E., Fradin D., Jarry A., Nguyen T., Labarrière N., Increased antitumor efficacy of PD-1- deficient melanoma-specific human lymphocytes. Journal for Immunotherapy of Cancer., 2020, vol 8, e000311. Réf. HAL: inserm-02481085

Mesnard C., Bodet-Milin C., Eugène T., Nguyen J.M., Khammari A., Dréno B., Predictive value of FDG‐PET imaging for relapse in metastatic melanoma patients treated with immunotherapy. Journal of the European Academy of Dermatology and Venereology., 2020, vol 34, n°10, 2261-2267 p. Réf. HAL: inserm-03498585

Michaud A.V., Samain B., Ferrer L., Fleury V., Doré M., Colombié M., Dupuy C., Rio E., Guimas V., Rousseau T., Le Thiec M., Delpon G., Rousseau C., Supiot S., Haute Couture or Ready-To-Wear? Tailored Pelvic Radiotherapy for Prostate Cancer Based on Individualized Sentinel Lymph Node Detection. Cancers., 2020, vol 12, n°4, 944 p. Réf. HAL: inserm-02908764

Michaud-Robert A.V., Jamet B., Bailly C., Carlier T., Moreau P., Touzeau C., Bourgeois M., Kraeber-Bodéré F., Bodet-Milin C., FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients? Cancers., 2020, vol 12, n°6, 1384 p. Réf. HAL: inserm-02908787

Michaud-Robert A.V., Zamagni E., Carlier T., Bailly C., Jamet B., Touzeau C., Moreau P., Kraeber-Bodere F., Nanni C., Bodet-Milin C., Glucose Metabolism Quantified by SUVmax on Baseline FDG-PET/CT Predicts Survival in Newly Diagnosed Multiple Myeloma Patients: Combined Harmonized Analysis of Two Prospective Phase III Trials. Cancers., 2020, vol 12, n°9, 2532 p. Réf. HAL: inserm-03497417

Millardet M., Moussaoui S., Mateus D., Idier J., Carlier T., Local-mean preserving post-processing step for non-negativity enforcement in PET imaging: application to 90 Y-PET. IEEE Transactions on Medical Imaging., 2020, vol 39, 3725 – 3736 p. Réf. HAL: hal-02565204

Morel A., Maucherat B., Chiavassa S., Kraeber-Bodéré F., Rousseau C., Long-term Trace of Radiation Pneumonitis With 18F-Fluoroestradiol. Clinical Nuclear Medicine., 2020, vol 45, e403 – e405. Réf. HAL: inserm-03006971

Pallardy A., Rousseau C., Labbe C., Liberge R., Bodet-Milin C., Kraeber-Bodere F., Fleury V., Incidental findings suggestive of COVID-19 in asymptomatic cancer patients undergoing 18F-FDG PET/CT in a low prevalence region. European Journal of Nuclear Medicine and Molecular Imaging., 2020, Online ahead of print. Réf. HAL: inserm-03007003

Parrot T., Oger R., Allard M., Desfrançois J., Raingeard De La Blétìère D., Coutolleau A., Preisser L., Khammari A., Dréno B., Delneste Y., Guardiola P., Fradin D., Gervois N., Transcriptomic features of tumour- infiltrating CD4 low CD8 high double positive αβ T cells in melanoma. Scientific Reports., 2020, vol 10, n°1, 5900 p. Réf. HAL: inserm-02534481

Perrin J., Capitao M., Mougin-Degraef M., Guérard F., Faivre-Chauvet A., Rbah-Vidal L., Gaschet J., Guilloux Y., Kraeber-Bodéré F., Chérel M., Barbet J., Cell Tracking in Cancer Immunotherapy. Frontiers in Medicine., 2020, vol 7, 34 p. Réf. HAL: inserm-02512946

Pichon B., Rousseau C., Blanc-Lapierre A., Delpon G., Ferrer L., Libois V., Le Turnier M., Lenoble C., Bodet-Milin C., Goldenberg D., Kraeber-Bodere F., Supiot S., Targeting Stereotactic Body Radiotherapy on Metabolic PET- and Immuno-PET-Positive Vertebral Metastases. Biomedicines., 2020, vol 8, n°12, 548 p. Réf. HAL: inserm-03500271

Rousseau C., Goldenberg D. M, Colombié M., Sébille J.C., Meingan P., Ferrer L., Baumgartner P., Cerato E. M, Masson D., Campone M., Rauscher A., Fleury V., Labbé C., Faivre-Chauvet A., Fresnel J.S., Toquet C., Barbet J., Sharkey R. M, Campion L., Kraeber-Bodéré F., Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer. Journal of Nuclear Medicine., 2020, jnumed.119.236000. Réf. HAL: inserm-02512957

Sébille J.C., Eugene T., Carlier T., Kraeber-Bodere F., Bailly C., Khammari A., Dreno B., Bodet-Milin C., Intérêt pronostique et prédictif de la TEP-TDM au 18F-FDG au bilan initial des mélanomes de stade IIIB-C-D et IV avant traitement par anti-PD-1. Médecine Nucléaire., 2020, vol 44, n°1, 65-71 p. Réf. HAL: inserm-03498679

Vidal A., Bourdeau C., Frindel M., Garcia T., Haddad F., Faivre-Chauvet A., Bourgeois M., ARRONAX Cyclotron: Setting up of In-HouseHospital Radiopharmacy. BioMed Research International ., 2020, vol 2020, 1572841 p. Réf. HAL: inserm-02908812

Zamagni E., Nanni C., Dozza L., Carlier T., Bailly C., Tacchetti P., Versari A., Chauvie S., Gallamini A., Gamberi B., Caillot D., Patriarca F., Macro M., Boccadoro M., Garderet L., Barbato S., Fanti S., Perrot A., Gay F., Sonneveld P., Karlin L., Cavo M., Bodet-Milin C., Moreau P., Kraeber-Bodéré F., Standardization of 18 F-FDG-PET/CT According to Deauville Criteria for Metabolic Complete Response Definition in Newly Diagnosed Multiple Myeloma. Journal of Clinical Oncology., 2020, vol 38, Online ahead of print. Réf. HAL: inserm-03007037

Ferrer L., Maucherat B., Carlier T., Kraeber-Bodéré F., Rousseau C., Preliminary comparative results between FES and FDG in ER plus metastatic breast cancer: a radiomic approach, 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47 333-334. Réf. HAL: inserm-03498659

Barbaud M., Touchefeu Y., Le Bras M., Fleury V., Carlier T., Bailly C., Frampas E., Rauscher A., Kraeber-Bodéré F., Ansquer C., Prognostic impact of phenotype heterogeneity of grade 1-2 metastatic gastroenteropancreatic neuroendocrine tumors documented by 18FDG PET-CT and 68Ga-DOTANOC PET-CT, 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47(EP-157):S585. Réf. HAL: inserm-03498714

Chalampalakis Z., Stute S., Filipovic M., Marie S., Bottlaender M., Tournier N., Comtat C., Application of a generic dynamic reconstruction algorithm on PET whole-body pharmacokinetic studies, 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22-30 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47(OP-839):S416. Réf. HAL: inserm-03495919

Gouard S., Marionneau-Lambot S., Gaschet J., Chouin S., Haddad F., Alliot C., Gestin J.F., Guérard F., Kraeber-Bodéré F., Chérel M., Targeted alpha-therapy with 211At-anti-mCD138 mAb in a syngeneic murine Multiple Myeloma model : can repeated doses or fractionation protocol overpass single dose efficiency? 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47 S410-S411. Réf. HAL: inserm-03500243

Moreau N., Rousseau C., Fourcade C., Santini G., Ferrer L., Lacombe M., Guillerminet C., Campone M., Colombié M., Rubeaux M., Normand N., Deep learning approaches for bone and bone lesion segmentation on 18 FDG PET/CT imaging in the context of metastatic breast cancer*, 2020, EMBC – Engineering in Medecine and Biology Conference, 20 juillet 2020, Montréal (Canada).. Réf. HAL: hal-02591573

Morel A., Fleury V., Le Thiec M., Maucherat B., Colombié M., Rusu D., Aillet G., Kraeber-Bodéré F., Rousseau T., Campion L., Rousseau C., Between pathological prostate cancer lymph node and sentinel lymph node status : which one is the most informative? 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22-30 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47(OP-418):S210. Réf. HAL: inserm-03496198

Santini G., Fourcade C., Moreau N., Rousseau C., Ferrer L., Lacombe M., Fleury V., Campone M., Jézéquel P., Rubeaux M., Unpaired PET/CT image synthesis of liver region using CycleGAN, 2020, 16th International Symposium on Medical Information Processing and Analysis, 3-4 octobre 2020, Lima (Pérou). 6. Réf. HAL: inserm-03500317

Berdal M., Guérard F., Gestin J.F., Faivre-Chauvet A., Method for Radioiodination or Radioastatination of a biomolecule Patent n°WO 2020/221744 A1 (2020). Réf. HAL: inserm-03013584

Bailly C., Bodet-Milin C. M, Rousseau C., Guérard F., Carlier T., Ferrer L., Chouin N., Gaschet J., Haddad F., Chérel M., Barbet J. F, Kraeber-Bodéré F., Bourgeois M., New Advances in Radioimmunotherapy for the Treatment of Cancers, Bench to Bedside Immunotherapy of Cancers. Cancer Immunology, Springer, 563-585 p, 2020. Réf. HAL: inserm-03016103

Kalichuk V., Kambarev S., Béhar G., Chalopin B., Renodon-Cornière A., Mouratou B., Pecorari F., Affitins: Ribosome Display for Selection of Aho7c-Based Affinity Proteins, Genotype Phenotype Coupling, 19-41 p, 2020. Réf. HAL: inserm-02337107

Morvan L., Nanni C., Michaud A.V., Jamet B., Bailly C., Bodet-Milin C., Chauvie S., Touzeau C., Moreau P., Zamagni E., Kraeber-Bodéré F., Carlier T., Mateus D., Learned Deep Radiomics for Survival Analysis with Attention, Predictive Intelligence in Medicine (PRIME) 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, 35-45 p, 2020. Réf. HAL: hal-03266299

Colombie M., Rauscher A., Frindel M., Cherel M., Haddad F., Rousseau C., Fleury V., Kraeber Bodéré F., Vidal A., Bourgeois M., Essai clinique autour d’un radiopharmaceutique innovant : le 64Cu-ATSM comme facteur prédictif de la réponse au traitement néo-adjuvant dans le cancer du rectum, 2020, 6èmes Journées Francophones de Médecine Nucléaire, 26-28 mars 2020, Paris (France). Médecine Nucléaire, 44(2):93. Réf. HAL: hal-02914657

Fourcade C., Ferrer L., Santini G., Moreau N., Rousseau C., Lacombe M., Guillerminet C., Colombié M., Campone M., Mateus D., Rubeaux M., Combining Superpixels and Deep Learning Approaches to Segment Active Organs in Metastatic Breast Cancer PET Images *, 2020, EMBC – Engineering in Medecine and Biology Conference, 20 juillet 2020, Montréal (Canada).. Réf. HAL: hal-02565092

Fourcade C., Santini G., Ferrer L., Rousseau C., Colombié M., Campone M., Rubeaux M., Mateus D., Active Organs Segmentation in Metastatic Breast Cancer Images combining Superpixels and Deep Learning Methods, 2020, NTHS – Nuclear Technology for Health Symposium, 13-14 février 2020, Nantes (France).. Réf. HAL: hal-02565107

Morvan L., Carlier T., Mateus D., The Limitations of Deep Learning: A Focus on Survival Analysis with PET Images., 2020, 4th Nuclear Technologies for Health Symposium (NTHS 2020), 13 février 2020, Nantes (France).. Réf. HAL: hal-02569261

Rousseau C., Ferrer L., Le Thiec M., Fleury V., Frindel M., Rusu D., Maucherat B., Rauscher A., Baumgartner P., Morel A., Varmenot N., Campion L., Kraeber‐bodéré F., 68 Ga‐PSMA PET/CT prospective study in prostate cancer patients with occult recurrence: Diagnostic performance and impact on therapeutic decision‐making and long-term benefits, 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22-30 octobre 2020, Virtuel (France). 47(OP-641):S323. Réf. HAL: inserm-03495609

Equipe 03 « Senescence escape and soluble markers of cancer progression »

Caillot M., Bourgeais J., Dakik H., Costé É., Mazure N., Lelièvre É., Coqueret O., Herault O., Mazurier F., Sola B., Oncogenesis Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells. Oncogenesis., 2020, vol 9, n°7, 68 p. Réf. HAL: hal-02908131

Decourcelle A., Very N., Djouina M., Loison I., Thevenet J., Body-Malapel M., Lelièvre E., Coqueret O., Leprince D., El Yazidi-Belkoura I., Dehennaut V., O-GlcNAcylation Links Nutrition to the Epigenetic Downregulation of UNC5A during Colon Carcinogenesis. Cancers., 2020, vol 12, n°11, 3168 p. Réf. HAL: hal-03110218

Delaunay T., Nader J., Grard M., Farine I., Hedwig V., Foloppe J., Blondy T., Violland M., Pouliquen D. L., Grégoire M., Boisgerault N., Erbs P., Fonteneau J.F., High oncolytic activity of a double deleted Vaccinia Virus Copenhagen strain against malignant pleural mesothelioma : Mesothelioma and oncolytic vaccinia virus. Molecular Therapy – Oncolytics., 2020, Online ahead of print. Réf. HAL: inserm-02913764

Jézéquel P., Patsouris A., Guette C., Juin P., Campone M., RE: Immune checkpoint profiles in luminal B breast cancer (Alliance). JNCI: Journal of the National Cancer Institute., 2020, djaa037. Réf. HAL: inserm-02524151

Nader J. S, Boissard A., Henry C., Valo I., Verrièle V., Grégoire M., Coqueret O., Guette C., Pouliquen D. L, Cross-Species Proteomics Identifies CAPG and SBP1 as Crucial Invasiveness Biomarkers in Rat and Human Malignant Mesothelioma. Cancers., 2020,. Réf. HAL: inserm-02945810

Nader J. L, Guillon J., Petit C., Boissard A., Franconi F., Blandin S., Lambot S., Gregoire M., Verriele V., Nawrocki-Raby B., Birembaut P., Coqueret O., Guette C., Pouliquen D. L., S100A4 Is a Biomarker of Tumorigenesis, EMT, Invasion, and Colonization of Host Organs in Experimental Malignant Mesothelioma. Cancers., 2020, vol 12, n°4, E939. Réf. HAL: inserm-02546002

Pouliquen D. L., Boissard A., Coqueret O., Guette C., Biomarkers of tumor invasiveness in proteomics (Review). International Journal of Oncology., 2020, vol 57, n°2, 409-432 p. Réf. HAL: inserm-02909126

Pouliquen D. L., Boissard A., Henry C., Blandin S., Richomme P., Coqueret O., Guette C., Curcumin Treatment Identifies Therapeutic Targets within Biomarkers of Liver Colonization by Highly Invasive Mesothelioma Cells—Potential Links with Sarcomas. Cancers., 2020, vol 12, n°11, 3384 p. Réf. HAL: inserm-03013573

Equipe 04 « Innate Immunity and Immunotherapy »

Abbara C., Drevin G., Férec S., Ghamrawi S., Souchet S., Robin J.B., Schmidt A., Hunault-Berger M., Guardiola P., Briet M., Slower degradation rate of cytarabine in blood samples from acute myeloid leukemia by comparison with control samples. Cancer Chemotherapy and Pharmacology., 2020, vol 86, n°5, 687-691 p. Réf. HAL: inserm-03498936

Billaud A., Chevalier L.M., Campone M., Morel A., Bigot F., L’instabilité génomique, paramètre limitant l’efficacité des thérapies ciblées en oncologie. Bulletin du Cancer., 2020, vol S0007-4551, n°20, 30373-8 p. Réf. HAL: inserm-02978363

Blondy T., Mickael D’almeida S., Briolay T., Tabiasco J., Meiller C., Chéné A.L., Cellerin L., Deshayes S., Delneste Y., Fonteneau J.F., Boisgerault N., Bennouna J., Grégoire M., Jean D., Blanquart C., Involvement of the M-CSF/IL-34/CSF- 1R pathway in malignant pleural mesothelioma. Journal for Immunotherapy of Cancer., 2020, vol 8, n°1, e000182. Réf. HAL: inserm-02913733

Bouet P.E., Boueilh T., Chao De La Barca J. Manuel, Boucret L., Blanchard S. J., Ferré-L’hotellier V., Jeannin P., Descamps P., Procaccio V., Reynier P., May-Panloup P., The cytokine profile of follicular fluid changes during ovarian ageing. Journal of Gynecology Obstetrics and Human Reproduction., 2020, 101704 p. Réf. HAL: inserm-02516754

Brilland B., Garnier A.S., Chevailler A., Jeannin P., Subra J.F., Augusto J.F., Complement alternative pathway in ANCA-associated vasculitis: Two decades from bench to bedside. Autoimmunity Reviews., 2020, vol 19, n°1, 102424 p. Réf. HAL: inserm-02519542

Caillard P., Vigneau C., Halimi J.M., Hazzan M., Thervet E., Heitz M., Juillard L., Audard V., Rabant M., Hertig A., Subra J.F., Vuiblet V., Guerrot D., Tamain M., Essig M., Lobbedez T., Quémeneur T., Rebibou J.M., Ganea A., Peraldi M.N., Vrtovsnik F., Daroux M., Lamrani A., Makdassi R., Choukroun G., Titeca-Beauport D., Severe Infection in Anti-Glomerular Basement Membrane Disease: A Retrospective Multicenter French Study. Journal of Clinical Medicine., 2020, vol 9, n°3, 698 p. Réf. HAL: hal-02796989

Chevalier L.M., Billaud A., Fronteau S., Dauvé J., Patsouris A., Verriele V., Morel A., Somatic mRNA Analysis of BRCA1 Splice Variants Provides a Direct Theranostic Impact on PARP Inhibitors. Molecular Diagnosis., 2020, Epub ahead of print. Réf. HAL: inserm-02512969

Chevalier L.M., Billaud A., Passot C., Renoult A., Bigot F., Verriele V., Morel A., [EGFR molecular characterization in non-small cell bronchic cancer: comparative prospective study by NGS and Idylla platform technologies]. Annales de Pathologie., 2020, S0242-6498(20)30031-6. Réf. HAL: inserm-02912690

Foulon M., Pouchin A., Manry J., Khater F., Robbe-Saule M., Durand A., Esnault L., Delneste Y., Jeannin P., Saint André J.P., Croué A., Altare F., Abel L., Alcaïs A., Marion E., Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection. Science Advances ., 2020, vol 6, n°9, eaax7781. Réf. HAL: inserm-02512893

Foulon M., Robbe-Saule M., Manry J., Esnault L., Boucaud Y., Alcaïs A., Malloci M., Fanton D’andon M., Beauvais T., Labarrière N., Jeannin P., Abel L., Saint-André J. P, Croué A., Delneste Y., Boneca I. G, Marsollier L., Marion E., Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology. PLoS Pathogens., 2020, vol 16, n°12, e1009107. Réf. HAL: inserm-03113905

Garnier A.S., Dellamaggiore J., Brilland B., Lagarce L., Abgueguen P., Furber A., Legrand E., Subra J.F., Drablier G., Augusto J.F., High Incidence of Amoxicillin-Induced Crystal Nephropathy in Patients Receiving High Dose of Intravenous Amoxicillin. Journal of Clinical Medicine., 2020, vol 9, n°7, 2022 p. Réf. HAL: inserm-03498318

Grégoire H., Roncali L., Rousseau A., Chérel M., Delneste Y., Hindré F., Garcion E., Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma. Frontiers., 2020, Epub ahead of print. Réf. HAL: inserm-02512928

Henry N., Brilland B., Wacrenier S., Djema A., Garnier A.S., Gansey R., Coindre J.P., Besson V., Duveau A., Subra J.F., Cousin M., Piccoli G.B., Augusto J.F., Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry. Journal of Clinical Medicine., 2020, vol 9, n°10, 3177 p. Réf. HAL: inserm-03498365

Kim R., Boissel N., Touzart A., Leguay T., Thonier F., Thomas X., Raffoux E., Huguet F., Villarese P., Fourrage C., Passini L., Hunault M., Leprêtre S., Chevallier P., Braun T., Lhéritier V., Chantepie S., Maury S., Escoffre M., Tavernier E., Chalandon Y., Graux C., Macintyre E., Ifrah N., Asnafi V., Dombret H., Lhermitte L., Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation. Leukemia., 2020, Epub ahead of print. Réf. HAL: inserm-02551756

Lacout C., Orvain C., Seegers V., De Vries M., Mercier M., Farhi J., Clavert A., Thepot S., Moles M., Ifrah N., Hunault‐Berger M., Schmidt A., R‐DHA‐oxaliplatin (R‐DHAOx) versus R‐DHA‐cisplatin (R‐DHAP) regimen in B‐cell lymphoma treatment: A eight‐year trajectory study. European Journal of Haematology., 2020, vol 105, n°2, 223-230 p. Réf. HAL: inserm-03498857

Lantier L., Poupée-Beaugé A., Di Tommaso A., Ducournau C., Epardaud M., Lakhrif Z., Germon S., Debierre-Grockiego F., Mévélec M.N., Battistoni A., Coënon L., Deluce-Kakwata-Nkor N., Velge-Roussel F., Beauvillain C., Baranek T., Lee G.S., Kervarrec T., Touzé A., Moiré N., Dimier-Poisson I., Neospora caninum: a new class of biopharmaceuticals in the therapeutic arsenal against cancer. Journal for Immunotherapy of Cancer., 2020, vol 8, n°2, 15 p. p. Réf. HAL: hal-03079434

Lenaers G., Bonneau D., Delneste Y., Papon N., Dysfunctional T Cell Mitochondria Lead to Premature Aging. Trends in Molecular Medicine., 2020, vol 26, n°9, 799-800 p. Réf. HAL: hal-02942791

Mahieu R., Tillard L., Le Guillou-Guillemette H., Vinatier E., Jeannin P., Croue A., Le Corre Y., Vandamme Y.M., No antibody response in acral cutaneous manifestations associated with COVID-19 ? Journal of the European Academy of Dermatology and Venereology., 2020, 10.1111/jdv.16688 p. Réf. HAL: inserm-02912696

Omarjee L., Mention P.J., Janin A., Kauffenstein G., Le Pabic E., Meilhac O., Blanchard S. J., Navasiolava N., Lefthériotis G., Couturier O., Jeannin P., Lacoeuille F., Martin L., Assessment of Inflammation and Calcification in Pseudoxanthoma Elasticum Arteries and Skin with 18F-FluroDeoxyGlucose and 18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography Imaging: The GOCAPXE Trial. Journal of Clinical Medicine., 2020, vol 9, n°11, 3448 p. Réf. HAL: hal-03000935

Orvain C., Balsat M., Tavernier E., Marolleau J.P., Pabst T., Chevallier P., De Gunzburg N., Cacheux V., Rigal-Huguet F., Chantepie S., Caillot D., Chalandon Y., Frayfer J., Bonmati C., Lheritier V., Ifrah N., Dombret H., Boissel N., Hunault-Berger M., Thromboembolism Prophylaxis in Adult Patients with Acute Lymphoblastic Leukemia Treated in the GRAALL-2005 Study. Blood., 2020, vol 136, n°3, 328-338. p. Réf. HAL: inserm-03500311

Paillassa J., Cornet E., Noël S., Tomowiak C., Lepretre S., Vaudaux S., Dupuis J., Devidas A., Joly B., Petitdidier-Lionnet C., Haiat S., Mariette C., Thieblemont C., Decaudin D., Validire-Charpy P., Drenou B., Eisenmann J.C., Uribe M.O., Olivrie A., Touati M., Lambotte O., Hermine O., Karsenti J.M., Feugier P., Vaillant W., Gutnecht J., Lippert E., Huysman F., Ghomari K., Boubaya M., Levy V., Riou J., Damaj G., Schmidt A., Hunault-Berger M., Troussard X., Analysis of a cohort of 279 patients with hairy-cell leukemia (HCL): 10 years of follow-up. Blood Cancer Journal., 2020, vol 10, n°5, 62 p. Réf. HAL: inserm-03495791

Paolini L., Adam C., Beauvillain C., Preisser L., Blanchard S., Pignon P., Seegers V., Chevalier L.M., Campone M., Wernert R., Verriele V., Raro P., Ifrah N., Lavoue V., Descamps P., Morel A., Catros V., Tcherkez G., Lenaers G., Bocca C., Kouassi Nzoughet J., Procaccio V., Delneste Y., Jeannin P., Lactic acidosis together with GM-CSF and M-CSF induces human macrophages toward an inflammatory pro-tumor phenotype. Cancer Immunology Research., 2020, vol 8, n°3, 383-395 p. Réf. HAL: hal-02442525

Paolini L., Adam C., Beauvillain C., Preisser L., Blanchard S. J., Pignon P., Seegers V., Chevalier L.M., Campone M., Wernert R., Verrielle V., Raro P., Ifrah N., Lavoué V., Descamps P., Morel A., Catros V., Tcherkez G., Lenaers G., Bocca C., Kouassi Nzoughet J., Procaccio V., Delneste Y., Jeannin P., Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype. Cancer Immunology Research., 2020, vol 8, n°3, 383 – 395 p. Réf. HAL: inserm-03377866

Papon N., Gangneux J.P., Delneste Y., Fungal Melanin Rewires Macrophage Metabolism. Trends in Biochemical Sciences., 2020, vol 45, n°9, 728-730 p. Réf. HAL: hal-02890535

Parrot T., Oger R., Allard M., Desfrançois J., Raingeard De La Blétìère D., Coutolleau A., Preisser L., Khammari A., Dréno B., Delneste Y., Guardiola P., Fradin D., Gervois N., Transcriptomic features of tumour- infiltrating CD4 low CD8 high double positive αβ T cells in melanoma. Scientific Reports., 2020, vol 10, n°1, 5900 p. Réf. HAL: inserm-02534481

Paz D. Luque, Jouanneau-Courville R., Riou J., Ianotto J.C., Boyer F., Chauveau A., Renard M., Chomel J.C., Cayssials E., Gallego-Hernanz M.P., Pastoret C., Murati A., Courtier F., Rousselet M.C., Quintin-Roué I., Cottin L., Orvain C., Thépot S., Chrétien J.M., Delneste Y., Ifrah N., Blanchet O., Hunault-Berger M., Lippert E., Ugo V., Leukemic evolution of polycythemia vera and essential thrombocythemia: genomic profiles predict time to transformation. Blood Advances., 2020, vol 4, n°19, 4887-4897 p. Réf. HAL: inserm-02970969

Planchais M., Brilland B., Demiselle J., Besson V., Duveau A., Croué A., Cousin M., Subra J.F., Augusto J.F., Garnier A.S., Renal biopsy in very elderly patients (over 80 years): clinical presentation, histological diagnosis, and long-term outcome. International Urology and Nephrology., 2020, vol 52, n°4, 721-729 p. Réf. HAL: inserm-03498887

Rohmer J., Couteau‐chardon A., Trichereau J., Panel K., Gesquiere C., Ben Abdelali R., Bidet A., Bladé J., Cayuela J., Cony‐makhoul P., Cottin V., Delabesse E., Ebbo M., Fain O., Flandrin P., Galicier L., Godon C., Grardel N., Guffroy A., Hamidou M., Hunault M., Lengline E., Lhomme F., Lhermitte L., Machelart I., Mauvieux L., Mohr C., Mozicconacci M., Naguib D., Nicolini F. E, Rey J., Rousselot P., Tavitian S., Terriou L., Lefèvre G., Preudhomme C., Kahn J., Groh M., Epidemiology, clinical picture and long‐term outcomes of FIP1L1‐PDGFRA ‐positive myeloid neoplasm with eosinophilia: Data from 151 patients. American Journal of Hematology., 2020, vol 95, n°11, 1314-1323 p. Réf. HAL: inserm-03496695

Soleti R., Mallegol P., Hilairet G., Frifra M., Perrin F., Dubois-Laurent C., Huet S., Pignon P., Basset L., Geoffriau E. E., Andriantsitohaina R., Carrot Genotypes Contrasted by Root Color and Grown under Different Conditions Displayed Differential Pharmacological Profiles in Vascular and Metabolic Cells. Nutrients., 2020,. Réf. HAL: hal-02469528

Tondeur S., Paul F., Riou J., Mansier O., Ranta D., Le Clech L., Lippert E., Tavitian S., Chaoui D., Mercier M., De Renzis B., Cottin L., Cassinat B., Chrétien J.M., Ianotto J.C., Allangba O., Marzac C., Voillat L., Boyer F., Orvain C., Hunault-Berger M., Girodon F., Kiladjian J.J., Ugo V., Luque Paz D., Long-term follow-up of JAK2 exon 12 polycythemia vera: a French Intergroup of Myeloproliferative Neoplasms (FIM) study. Leukemia., 2020, Online ahead of print. Réf. HAL: inserm-02978245

Wicker-Planquart C., Dufour S., Tacnet-Delorme P., Bally I., Delneste Y., Frachet P., Housset D., Thielens N. M., Molecular and Cellular Interactions of Scavenger Receptor SR-F1 With Complement C1q Provide Insights Into Its Role in the Clearance of Apoptotic Cells. Frontiers in Immunology., 2020,. Réf. HAL: hal-02529033

Collin L., Babin M., De Chabot G., Lhuissier M., Beauvillain C., Urban T., Morisset M., Successful one- bag desensitization protocol in a patient with pembrolizumab hypersensitivity, 2020, European-Academy-of-Allergology-and-Clinical-Immunology Digital Congress (EAACI), 6 juin 2020, Londres (Royaume-Uni). Allergy : European Journal of Allergy and Clinical Immunology,(1839) 603. Réf. HAL: inserm-03500267

Equipe 05 « Design and application of innovative loco-regional Treatments in Glioblastoma »

Bernard F., Lemée J.M., Mazerand E., Leiber L.M., Menei P., Ter Minassian A., The ventral attention network: the mirror of the language network in the right brain hemisphere. Journal of Anatomy., 2020, Online ahead of print. Réf. HAL: inserm-02912497

Berro D.H., Lemée J., Leiber L., Emery E., Menei P., Ter Minassian A., Overt speech feasibility using continuous functional magnetic resonance imaging: Isolation of areas involved in phonology and prosody. Journal of Neuroscience Research., 2020, vol 98, n°12, 2554-2565 p. Réf. HAL: hal-02948914

Clavreul A., Menei P., Mesenchymal Stromal-Like Cells in the Glioma Microenvironment: What Are These Cells? Cancers., 2020, vol 12, n°9, 2628 p. Réf. HAL: inserm-03374644

Delion M., Klinger E., Bernard F., Aubin G., Ter Minassian A., Menei P., Immersing Patients in a Virtual Reality Environment for Brain Mapping During Awake Surgery: Safety Study. World Neurosurgery., 2020, vol 134, e937-e943. Réf. HAL: hal-02510306

Fares M., Cochet-Bernoin M., Gonzalez G., Montero-Menei C., Blanchet O., Benchoua A., Boissart C., Lecollinet S., Richardson J., Haddad N., Coulpier M., Pathological modeling of TBEV infection reveals differential innate immune responses in human neurons and astrocytes that correlate with their susceptibility to infection. Journal of Neuroinflammation., 2020, vol 17, n°1, 76 p. Réf. HAL: inserm-02914090

Grégoire H., Roncali L., Rousseau A., Chérel M., Delneste Y., Hindré F., Garcion E., Targeting Tumor Associated Macrophages to Overcome Conventional Treatment Resistance in Glioblastoma. Frontiers., 2020, Epub ahead of print. Réf. HAL: inserm-02512928

Najberg M., Haji Mansor M., Taillé T., Bouré C., Molina-Peña R., Boury F., Cenis J. Luis, Garcion E., Alvarez-Lorenzo C., Aerogel sponges of silk fibroin, hyaluronic acid and heparin for soft tissue engineering: Composition-properties relationship. Carbohydrate Polymers., 2020, vol 237, 116107 p. Réf. HAL: inserm-02912531

Ndumiso M., Buchtová N., Husselmann L., Mohamed G., Klein A., Aucamp M., Canevet D., D’souza S., Maphasa R. E, Boury F., Dube A., Comparative whole corona fingerprinting and protein adsorption thermodynamics of PLGA and PCL nanoparticles in human serum. Colloids and Surfaces B: Biointerfaces., 2020, vol 188, 110816 p. Réf. HAL: hal-02778503

Oddone N., Boury F., Garcion E., Grabrucker A. M., Carmen Martinez M., Da Ros F., Janaszewska A., Forni F., Vandelli M. Angela, Tosi G., Ruozi B., Duskey J. T, Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal- Melphalan Prodrug for Glioblastoma Treatment. Frontiers in Pharmacology., 2020, vol 11, 574 p. Réf. HAL: inserm-02912540

Omarjee L., Mention P.J., Janin A., Kauffenstein G., Le Pabic E., Meilhac O., Blanchard S. J., Navasiolava N., Lefthériotis G., Couturier O., Jeannin P., Lacoeuille F., Martin L., Assessment of Inflammation and Calcification in Pseudoxanthoma Elasticum Arteries and Skin with 18F-FluroDeoxyGlucose and 18F-Sodium Fluoride Positron Emission Tomography/Computed Tomography Imaging: The GOCAPXE Trial. Journal of Clinical Medicine., 2020, vol 9, n°11, 3448 p. Réf. HAL: hal-03000935

Riaud M., Martínez M.C., Montero-Menei C. N, Scaffolds and Extracellular Vesicles as a Promising Approach for Cardiac Regeneration after Myocardial Infarction. Pharmaceutics., 2020, vol 12, n°12, 1195 p. Réf. HAL: hal-03404484

Simion V., Henriet E., Juric V., Aquino R., Loussouarn C., Laurent Y., Martin F., Midoux P., Garcion E., Pichon C., Baril P., Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system. Journal of Controlled Release., 2020, vol 327, 429-443 p. Réf. HAL: hal-02959393

Sourty B., Rousseau A., Prédisposition héréditaire aux tumeurs des systèmes nerveux central et périphérique. Annales de Pathologie., 2020, vol 40, 168 – 179 p. Réf. HAL: hal-03490420

Ugur D., Sottile V., Montero-Menei C., Boury F., Zelzer M., Relating polymeric microparticle formulation to prevalence or distribution of fibronectin and poly- d -lysine to support mesenchymal stem cell growth. Biointerphases., 2020, vol 15, n°4, 041008 p. Réf. HAL: inserm-03498875

Equipe 06 « Signaling in Oncogenesis, Angiogenesis and Permeability »

Alves Nicolau C., Gavard J., Bidère N., TAK1 lessens the Activity of the Paracaspase MALT1 during T cell Receptor Signaling. Cellular Immunology., 2020, 104115 p. Réf. HAL: inserm-02558368

Douanne T., Chapelier S., Rottapel R., Gavard J., Bidère N., The LUBAC participates in lysophosphatidic acid-induced NF-κB activation. Cellular Immunology., 2020, vol 353, 104133 p. Réf. HAL: inserm-02786003

Jacobs K. A, Maghe C., Gavard J., Lysosomes in glioblastoma: pump up the volume. Cell Cycle., 2020, Online ahead of print. Réf. HAL: inserm-02908750

Maghe C., Jacobs K. A, Bidère N., Gavard J., Glioblastome multiforme : Les fleurs du MALT1. médecine/sciences., 2020, vol 36, n°5, 452-454 p. Réf. HAL: inserm-02785954

Sabbagh Q., André-Grégoire G., Guével L., Gavard J., Vesiclemia: counting on extracellular vesicles for glioblastoma patients. Oncogene., 2020,. Réf. HAL: inserm-02915935

Equipe 07 « Stress Adaptation and Tumor Escape »

Barillé-Nion S. C, Lohard S., Juin P., Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses? Biomolecules., 2020, vol 10, n°8, 1109 p. Réf. HAL: inserm-03319435

Ben Azzouz F., Michel B., Lasla H., Gouraud W., François A.F., Girka F., Lecointre T., Guérin-Charbonnel C., Juin P., Campone M., Jézéquel P., Development of an absolute assignment predictor for triple-negative breast cancer subtyping using machine learning approaches. Computers in Biology and Medicine., 2020, vol 129, 104171 p. Réf. HAL: inserm-03349338

Billaud A., Chevalier L.M., Campone M., Morel A., Bigot F., L’instabilité génomique, paramètre limitant l’efficacité des thérapies ciblées en oncologie. Bulletin du Cancer., 2020, vol S0007-4551, n°20, 30373-8 p. Réf. HAL: inserm-02978363

Dagher E., Simbault L., Abadie J., Loussouarn D., Campone M., Nguyen F., Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer. Tumor Biology., 2020, vol 42, n°1, 1010428319901052 p. Réf. HAL: inserm-02484624

Dumont A., Lohard S., Maillet L. A, Juin P., Barillé-Nion S. C, Noxa the BCL-2 Family Member behind the Scenes in Cancer Treatment. Journal of Cellular Signaling., 2020, vol 1, n°4, 127 p. Réf. HAL: inserm-03171678

Etienne F., Berthaud M., Nguyen F., Bernardeau K., Maurel C., Bodet-Milin C., Diab M., Abadie J., Gouilleux-Gruart V., Vidal A., Bourgeois M., Chouin N., Ibisch C., Davodeau F., SPECT-CT Imaging of Dog Spontaneous Diffuse Large B-Cell Lymphoma Targeting CD22 for the Implementation of a Relevant Preclinical Model for Human. Frontiers in Oncology., 2020, vol 10, 20 p. Réf. HAL: inserm-02512859

Guyon N., Garnier D., Briand J., Nadaradjane A., Bougras-Cartron G., Raimbourg J., Campone M., Heymann D., Vallette F. M, Frenel J.S., Cartron P.F., Anti-PD1 therapy induces lymphocyte-derived exosomal miRNA-4315 release inhibiting Bim-mediated apoptosis of tumor cells. Cell Death and Disease., 2020, vol 11, n°12, 1048 p. Réf. HAL: inserm-03495895

Jézéquel P., Patsouris A., Guette C., Juin P., Campone M., RE: Immune checkpoint profiles in luminal B breast cancer (Alliance). JNCI: Journal of the National Cancer Institute., 2020, djaa037. Réf. HAL: inserm-02524151

Lohard S., Bourgeois N., Maillet L. A, Gautier F. P, Fétiveau A., Lasla H., Nguyen F., Vuillier C., Dumont A., Moreau-Aubry A., Frapin M., David L., Loussouarn D., Kerdraon O., Campone M., Jézéquel P., Juin P., Barillé-Nion S., STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nature Communications., 2020, vol 11, n°1, 259 p. Réf. HAL: inserm-02448103

Lohard S., Juin P., Barillé-Nion S. C, Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics. Molecular & Cellular Oncology., 2020, vol 7, n°3, 1735912 p. Réf. HAL: inserm-03319352

Nguyen J.M., Juin P., Antonioli D., Moreau-Gaudry A., Campone M., Jézéquel P., Identification of paclitaxel resistance through a new statistical approach based on a random forest of perfect trees classifcation. Journal of Clinical Oncology., 2020, vol 38, n°15_suppl, e13513-e13513. Réf. HAL: inserm-03498332

Nocquet L., Juin P., Souazé F., Mitochondria at Center of Exchanges between Cancer Cells and Cancer-Associated Fibroblasts during Tumor Progression. Cancers., 2020, vol 12, n°10, 3017 p. Réf. HAL: inserm-02978374

Oizel K., Yang C., Renoult O., Gautier F., Do Q. N, Joalland N., Gao X., Ko B., Vallette F., Ge W.P., Paris F., Deberardinis R. J, Pecqueur C., Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model. Cancer and Metabolism., 2020, vol 8, 9 p. Réf. HAL: inserm-03013555

Paolini L., Adam C., Beauvillain C., Preisser L., Blanchard S. J., Pignon P., Seegers V., Chevalier L.M., Campone M., Wernert R., Verrielle V., Raro P., Ifrah N., Lavoué V., Descamps P., Morel A., Catros V., Tcherkez G., Lenaers G., Bocca C., Kouassi Nzoughet J., Procaccio V., Delneste Y., Jeannin P., Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype. Cancer Immunology Research., 2020, vol 8, n°3, 383 – 395 p. Réf. HAL: inserm-03377866

Seiller C., Maiga S., Touzeau C., Bellanger C., Kervoëlen C., Descamps G., Maillet L., Moreau P., Pellat-Deceunynck C., Gomez-Bougie P., Amiot M., Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/ BAK hetero-complexes. Cell Death and Disease., 2020, vol 11, 316 p. Réf. HAL: inserm-02563554

Moreau N., Rousseau C., Fourcade C., Santini G., Ferrer L., Lacombe M., Guillerminet C., Campone M., Colombié M., Rubeaux M., Normand N., Deep learning approaches for bone and bone lesion segmentation on 18 FDG PET/CT imaging in the context of metastatic breast cancer*, 2020, EMBC – Engineering in Medecine and Biology Conference, 20 juillet 2020, Montréal (Canada).. Réf. HAL: hal-02591573

Santini G., Fourcade C., Moreau N., Rousseau C., Ferrer L., Lacombe M., Fleury V., Campone M., Jézéquel P., Rubeaux M., Unpaired PET/CT image synthesis of liver region using CycleGAN, 2020, 16th International Symposium on Medical Information Processing and Analysis, 3-4 octobre 2020, Lima (Pérou). 6. Réf. HAL: inserm-03500317

Equipe 08 « Integrative Cancer Genomics »

Alberge J.B., Magrangeas F., Wagner M., Denié S., Guérin-Charbonnel C., Campion L., Attal M., Avet-Loiseau H., Carell T., Moreau P., Minvielle S., Sérandour A. A, DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma. Clinical Epigenetics., 2020, vol 12, 163 p. Réf. HAL: inserm-03006751

Briand J., Serandour A. A, Nadaradjane A., Bougras-Cartron G., Heymann D., Ory B., Vallette F. M., Cartron P.F., N6-Adenosine Methylation of miRNA-200b-3p Influences Its Functionality and Is a Theranostic Tool. Molecular Therapy – Nucleic Acids., 2020, vol 22, 72-83 p. Réf. HAL: hal-03004313

Corre J., Perrot A., Caillot D., Belhadj K., Hulin C., Leleu X., Mohty M., Facon T., Buisson L., Do Souto L., Lannes R., Dufrechou S., Prade N., Orsini-Piocelle F., Voillat L., Jaccard A., Karlin L., Macro M., Brechignac S., Dib M., Sanhes L., Fontan J., Filliatre‐clement L., Marolleau J.P., Minvielle S., Moreau P., Avet-Loiseau H., Del17p without TP53 mutation confers poor prognosis in intensively treated newly diagnosed multiple myeloma patients. Blood., 2020, blood.2020008346. Réf. HAL: inserm-03010010

Delaunay T., Achard C., Boisgerault N., Grard M., Petithomme T., Chatelain C., Dutoit S., Blanquart C., Royer P.J., Minvielle S., Quetel L., Meiller C., Jean D., Fradin D., Bennouna J., Magnan A., Cellerin L., Tangy F., Grégoire M., Fonteneau J.F., Frequent Homozygous Deletions of Type I Interferon Genes in Pleural Mesothelioma Confer Sensitivity to Oncolytic Measles Virus : Interferon genes loss sensitizes tumor cells to viral lysis. Journal of Thoracic Oncology., 2020, vol S1556-0864(20)30019-8, Epub ahead of print. Réf. HAL: inserm-02447160

Gac M.M., Loaec C., Silve J., Vaucel E., Augereau P., Wernert R., Bourgin C., Aireau X., Lortholary A., Descamps P., Priou F., Deblaye P., Bourgeois H., Delecroix V., Empereur F., Campion L., Classe J.M., Quality of advanced ovarian cancer surgery: A French assessment of ESGO quality indicators. EJSO – European Journal of Surgical Oncology., 2020, vol 47, n°2, 360 – 366 p. Réf. HAL: inserm-03349231

Goineau A., Campion L., Commer J.M., Vié B., Ghesquière A., Béra G., Jaffres D., Magné N., Artignan X., Chamois J., Bergerot P., Créhange G., Deniaud-Alexandre E., Buthaud X., Belkacémi Y., Doré M., De Decker L., Supiot S., Can Comprehensive Geriatric Assessment Predict Tolerance of Radiotherapy for Localized Prostate Cancer in Men Aged 75 Years or Older? Cancers., 2020, vol 12, n°3, 635 p. Réf. HAL: hal-03125251

Jamet B., Zamagni E., Nanni C., Bailly C., Carlier T., Touzeau C., Michaud A.V., Moreau P., Bodet-Milin C., Kraeber-Bodere F., Functional Imaging for Therapeutic Assessment and Minimal Residual Disease Detection in Multiple Myeloma. International Journal of Molecular Sciences., 2020, vol 21, n°15, 5406 p. Réf. HAL: inserm-03497317

Le Bris Y., Magrangeas F., Moreau A., Chiron D., Guérin-Charbonnel C., Theisen O., Pichon O., Canioni D., Burroni B., Maisonneuve H., Thieblemont C., Oberic L., Gyan E., Pellat-Deceunynck C., Hermine O., Delfau-Larue M.H., Tessoulin B., Béné M. C, Minvielle S., Le Gouill S., Whole genome copy number analysis in search of new prognostic biomarkers in first line treatment of mantle cell lymphoma. A study by the LYSA group. Hematological Oncology., 2020, Online ahead of print. Réf. HAL: inserm-02874026

Le Calvez B., Le Bris Y., Herbreteau G., Jamet B., Bossard C., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Antier C., Theisen O., Kraeber-Bodéré F., Le Gouill S., Béné M.C., Moreau P., Touzeau C., RASmutation leading to acquired resistance to dabrafenib and trametinib therapy in a multiplemyeloma patient harboring BRAF mutation. European Journal of Haematology., 2020, Online ahead of print. Réf. HAL: inserm-02874002

Le Thiec M., Testard A., Ferrer L., Guillerminet C., Morel O., Maucherat B., Rusu D., Girault S., Lacombe M., Hamidou H., Guérin Meyer V., Rio E., Hiret S., Kraeber-Bodéré F., Campion L., Rousseau C., Prognostic Impact of Pretherapeutic FDG-PET in Localized Anal Cancer. Cancers., 2020, vol 12, n°6, 1512 p. Réf. HAL: inserm-02908736

Marotte L., Simon S., Vignard V., Dupré E., Gantier M., Cruard J., Alberge J.B., Hussong M., Deleine C., Heslan J.M., Shaffer J., Beauvais T., Gaschet J., Scotet E., Fradin D., Jarry A., Nguyen T., Labarrière N., Increased antitumor efficacy of PD-1- deficient melanoma-specific human lymphocytes. Journal for Immunotherapy of Cancer., 2020, vol 8, e000311. Réf. HAL: inserm-02481085

Mehmet Kemal S., Aktas Samur A., Fulciniti M., Szalat R., Han T., Shammas M., Richardson P., Magrangeas F., Minvielle S., Corre J., Moreau P., Thakurta A., Anderson K.C., Parmigiani G., Avet-Loiseau H., Munshi N., Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group. Journal of Clinical Oncology., 2020, vol 38, JCO2000461. Réf. HAL: inserm-02913784

Michaud-Robert A.V., Jamet B., Bailly C., Carlier T., Moreau P., Touzeau C., Bourgeois M., Kraeber-Bodéré F., Bodet-Milin C., FDG-PET/CT, a Promising Exam for Detecting High-Risk Myeloma Patients? Cancers., 2020, vol 12, n°6, 1384 p. Réf. HAL: inserm-02908787

Michaud-Robert A.V., Zamagni E., Carlier T., Bailly C., Jamet B., Touzeau C., Moreau P., Kraeber-Bodere F., Nanni C., Bodet-Milin C., Glucose Metabolism Quantified by SUVmax on Baseline FDG-PET/CT Predicts Survival in Newly Diagnosed Multiple Myeloma Patients: Combined Harmonized Analysis of Two Prospective Phase III Trials. Cancers., 2020, vol 12, n°9, 2532 p. Réf. HAL: inserm-03497417

Moreau-Bachelard C., Campion L., Robert M., Kerdraon O., Renaudeau C., Aumont M., Classe J.M., Campone M., Frénel J.S., Development of a Prognostic Tool to Guide the Decision to Extend Adjuvant Aromatase Inhibitors for up to Ten Years in Postmenopausal Early Breast Cancer Patients. Cancers., 2020, vol 12, n°12, 3725 p. Réf. HAL: inserm-03496441

Rousseau C., Goldenberg D. M, Colombié M., Sébille J.C., Meingan P., Ferrer L., Baumgartner P., Cerato E. M, Masson D., Campone M., Rauscher A., Fleury V., Labbé C., Faivre-Chauvet A., Fresnel J.S., Toquet C., Barbet J., Sharkey R. M, Campion L., Kraeber-Bodéré F., Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in HER2-negative Breast Cancer. Journal of Nuclear Medicine., 2020, jnumed.119.236000. Réf. HAL: inserm-02512957

Rustad E., Yellapantula V., Glodzik D., Maclachlan K., Diamond B., Boyle E., Ashby C., Blaney P., Gundem G., Hultcrantz M., Leongamornlert D., Angelopoulos N., Agnelli L., Auclair D., Zhang Y., Dogan A., Bolli N., Papaemmanuil E., Anderson K., Moreau P., Avet-Loiseau H., Munshi N., Keats J., Campbell P., Morgan G., Landgren O., Maura F., Revealing the Impact of Structural Variants in Multiple Myeloma. Blood Cancer Discovery., 2020, vol 1, n°3, 258-273 p. Réf. HAL: inserm-03498917

Rustad E., Yellapantula V., Leongamornlert D., Bolli N., Ledergor G., Nadeu F., Angelopoulos N., Dawson K., Mitchell T., Osborne R., Ziccheddu B., Carniti C., Montefusco V., Corradini P., Anderson K., Moreau P., Papaemmanuil E., Alexandrov L., Puente X., Campo E., Siebert R., Avet-Loiseau H., Landgren O., Munshi N., Campbell P., Maura F., Timing the initiation of multiple myeloma. Nature Communications., 2020, vol 11, n°1, 1917 p. Réf. HAL: inserm-03500314

Seiller C., Maiga S., Touzeau C., Bellanger C., Kervoëlen C., Descamps G., Maillet L., Moreau P., Pellat-Deceunynck C., Gomez-Bougie P., Amiot M., Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/ BAK hetero-complexes. Cell Death and Disease., 2020, vol 11, 316 p. Réf. HAL: inserm-02563554

Sortais C., Lok A., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Touzeau C., Moreau A., Bossard C., Peterlin P., Garnier A., Guillaume T., Le Bourgeois A., Chevallier P., Moreau P., Leux C., Le Gouill S., Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life. Annals of Hematology., 2020, vol 99, n°7, 1595-1604 p. Réf. HAL: inserm-03498746

Morel A., Fleury V., Le Thiec M., Maucherat B., Colombié M., Rusu D., Aillet G., Kraeber-Bodéré F., Rousseau T., Campion L., Rousseau C., Between pathological prostate cancer lymph node and sentinel lymph node status : which one is the most informative? 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22-30 octobre 2020, Virtuel (France). European Journal of Nuclear Medicine and Molecular Imaging, 47(OP-418):S210. Réf. HAL: inserm-03496198

Rousseau C., Ferrer L., Le Thiec M., Fleury V., Frindel M., Rusu D., Maucherat B., Rauscher A., Baumgartner P., Morel A., Varmenot N., Campion L., Kraeber‐bodéré F., 68 Ga‐PSMA PET/CT prospective study in prostate cancer patients with occult recurrence: Diagnostic performance and impact on therapeutic decision‐making and long-term benefits, 2020, 33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), 22-30 octobre 2020, Virtuel (France). 47(OP-641):S323. Réf. HAL: inserm-03495609

Equipe 09 « Chromatin and Transcriptional Deregulation in Pediatric Bone Sarcoma »

Equipe 10 « Plasticity of Ecosystem from the Tumor after Radiotherapy »

Averbeck D., Candéias S. M., Chandna S., Foray N., Friedl A., Haghdoost S., Jeggo P., Lumniczky K., Paris F., Quintens R., Sabatier L., Establishing mechanisms affecting the individual response to ionising radiation. International Journal of Radiation Biology., 2020, vol 96, n°3, 297-323 p. Réf. HAL: hal-02431625

Clément-Colmou K., Potiron V. A., Pietri M., Guillonneau M., Jouglar E., Chiavassa S., Delpon G., Paris F., Supiot S., Influence of Radiotherapy Fractionation Schedule on the Tumor Vascular Microenvironment in Prostate and Lung Cancer Models. Cancers., 2020,. Réf. HAL: inserm-02426486

Dufresne S., Guéritat J., Chiavassa S., Noblet C., Assi M., Rioux-Leclercq N., Rannou-Bekono F., Lefeuvre-Orfila L., Paris F., Rébillard A., Exercise training improves radiotherapy efficiency in a murine model of prostate cancer. FASEB Journal., 2020, vol 34, n°4, 4984-4996 p. Réf. HAL: hal-02498421

Ketteler J., Wittka A., Leonetti D., Roy V. Veas, Estephan H., Maier P., Reis H., Herskind C., Jendrossek V., Paris F., Klein D., Caveolin-1 regulates the ASMase/ceramide- mediated radiation response of endothelial cells in the context of tumor-stroma interactions. Cell Death and Disease., 2020, vol 11, n°4, 228 p. Réf. HAL: inserm-02550200

Leonetti D., Estephan H., Ripoche N., Dubois N., Aguesse A., Gouard S., Brossard L., Chiavassa S., Corre I., Neunlist M., Hadchity E., Gaugler M.H., Mahé M., Paris F., Secretion of acid sphingomyelinase and ceramide by endothelial cells contributes to radiation induced intestinal toxicity. Cancer Research., 2020,. Réf. HAL: inserm-02539662

Michaud A.V., Samain B., Ferrer L., Fleury V., Doré M., Colombié M., Dupuy C., Rio E., Guimas V., Rousseau T., Le Thiec M., Delpon G., Rousseau C., Supiot S., Haute Couture or Ready-To-Wear? Tailored Pelvic Radiotherapy for Prostate Cancer Based on Individualized Sentinel Lymph Node Detection. Cancers., 2020, vol 12, n°4, 944 p. Réf. HAL: inserm-02908764

Mignard V., Dubois N., Lanoé D., Joalland M.P. M, Oliver L., Pecqueur C., Heymann D., Paris F., Vallette F. M, Lalier L., Sphingolipids distribution at mitochondria-associated membranes (MAM) upon induction of apoptosis. Journal of Lipid Research., 2020, 32350079 p. Réf. HAL: inserm-02625440

Oizel K., Yang C., Renoult O., Gautier F., Do Q. N, Joalland N., Gao X., Ko B., Vallette F., Ge W.P., Paris F., Deberardinis R. J, Pecqueur C., Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model. Cancer and Metabolism., 2020, vol 8, 9 p. Réf. HAL: inserm-03013555

Pariset E., Penninckx S., Degorre C., Guiet E., Lopez Macha A., Cekanaviciute E., Snijders A. M., Mao J.H., Paris F., Costes S., 53BP1 Repair Kinetics for Prediction of In Vivo Radiation Susceptibility in 15 Mouse Strains. Radiation Research., 2020, Online ahead of print. Réf. HAL: inserm-02978409

Perpoil A., Grimandi G., Birklé S., Simonet J.F., Chiffoleau A., Bocquet F., Public Health Impact of Using Biosimilars, Is Automated Follow up Relevant? International Journal of Environmental Research and Public Health., 2020, vol 18, n°1, 186 p. Réf. HAL: inserm-03095073

Rabé M., Dumont S., Álvarez-Arenas A., Janati H., Belmonte-Beitia J., Calvo G. F, Thibault-Carpentier C., Séry Q., Chauvin C., Joalland N., Briand F., Blandin S., Scotet E., Pecqueur C., Clairambault J., Oliver L., Pérez-García V., Nadaradjane A. M, Cartron P.F., Gratas C., Vallette F., Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma. Cell Death and Disease., 2020,. Réf. HAL: hal-02429194

Salaud C., Alvarez-Arenas A., Geraldo F., Belmonte-Beitia J., Calvo G. F, Gratas C., Pecqueur C., Garnier D., Pérez-Garcià V., Vallette F. M, Oliver L., Mitochondria transfer from tumor-activated stromal cells (TASC) to primary Glioblastoma cells. Biochemical and Biophysical Research Communications., 2020, vol 533, 139 – 147 p. Réf. HAL: inserm-03013565

Equipe 11 « Molecular Vulnerabilities of Tumor Escape in mature B-cell Malignancies »

Allain-Maillet S., Bosseboeuf A., Mennesson N., Bostoën M., Dufeu L., Choi E. Ho, Cleyrat C., Mansier O., Lippert E., Le Bris Y., Gombert J.M., Girodon F., Pettazzoni M., Bigot-Corbel E., Hermouet S., Anti-Glucosylsphingosine Autoimmunity, JAK2V617F-Dependent Interleukin-1β and JAK2V617F-Independent Cytokines in Myeloproliferative Neoplasms. Cancers., 2020, vol 12, n°9, E2446. Réf. HAL: inserm-02945854

Bailly C., Carlier T., Berriolo-Riedinger A., Casasnovas O., Gyan E., Meignan M., Moreau A., Burroni B., Djaileb L., Gressin R., Devillers A., Lamy T., Thieblemont C., Hermine O., Kraeber-Bodéré F., Le Gouill S., Bodet-Milin C. M, Prognostic value of FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project. Haematologica., 2020, vol 104, n°1, e33-e36. Réf. HAL: inserm-02266351

Bailly C., Carlier T., Kraeber-Bodéré F., Le Gouill S., Bodet-Milin C., Prognostic value of F-18-FDG-PET in patients with mantle cell lymphoma: results from the LyMa-PET Project Reply. Haematologica., 2020, vol 105, n°1, e42-e42. Réf. HAL: inserm-03498726

Bailly C., Carlier T. M, Kraeber-Bodéré F., Le Gouill S. L, Bodet-Milin C., Reply to E. Laffon et al. Haematologica., 2020,. Réf. HAL: inserm-02908548

Béné M., De Carvalho-Bittencourt M., Eveillard M., Le Bris Y., Good IgA Bad IgG in SARS-CoV-2 Infection? Clinical Infectious Diseases., 2020, vol 71, n°15, 897-898 p. Réf. HAL: hal-02971254

Delfau-Larue M.H., Boulland M.L., Beldi-Ferchiou A., Feugier P., Maisonneuve H., Casasnovas R.O., Lemonnier F., Pica G.M., Houot R., Ysebaert L., Tilly H., Eisenmann J.C., Le Gouill S., Ribrag V., Godmer P., Glaisner S., Cartron G., Xerri L., Salles G.A., Fest T., Morschhauser F., Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study. Blood Advances., 2020, vol 4, n°14, 3217-3223 p. Réf. HAL: inserm-03498367

Eveillard M., Rustad E., Roshal M., Zhang Y., Ciardiello A., Korde N., Hultcrantz M., Lu S., Shah U., Hassoun H., Smith E., Lesokhin A., Mailankody S., Landgren O., Thoren K., Comparison of MALDI‐TOF mass spectrometry analysis of peripheral blood and bone marrow‐based flow cytometry for tracking measurable residual disease in patients with multiple myeloma. British Journal of Haematology., 2020, Epub ahead of print. Réf. HAL: inserm-02534427

Hueso T., Gastinne T., Garciaz S., Tchernonog E., Delette C., Casasnovas R.O., Durot E., Houot R., Tessoulin B., Tournilhac O., Malak S., Gyan E., Fornecker L.M., Abraham J., Delapierre B., Peyrade F., Lemal R., Gressin R., Chantepie S., Borel C., Morello R., Bouabdallah K., Ibrahim A., Bouabdallah R., Le Gouill S., Damaj G., Bendamustine-EAM versus BEAM regimen in patients with mantle cell lymphoma undergoing autologous stem cell transplantation in the frontline setting: a multicenter retrospective study from Lymphoma Study Association (LYSA) centers. Bone Marrow Transplantation., 2020, vol 55, n°6, 1076-1084 p. Réf. HAL: hal-02500667

Jullien M., Gomez-Bougie P., Chiron D., Touzeau C., Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies. Cells., 2020, vol 9, n°3, E717. Réf. HAL: inserm-02512852

Lazarian G., Friedrich C., Quinquenel A., Tran J., Ouriemmi S., Dondi E., Martin A., Mihoub I., Chiron D., Bellanger C., Fleury •. Carole, Gélébart P., Mccormack E., Ledoux D., Thieblemont C., Marzec J., Gribben J., Cymbalista F., Varin-Blank N., Gardano L., Baran-Marszak F., Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma. Oncogene., 2020, vol 39, n°14, 2934-2947 p. Réf. HAL: inserm-02534412

Le Bris Y., Magrangeas F., Moreau A., Chiron D., Guérin-Charbonnel C., Theisen O., Pichon O., Canioni D., Burroni B., Maisonneuve H., Thieblemont C., Oberic L., Gyan E., Pellat-Deceunynck C., Hermine O., Delfau-Larue M.H., Tessoulin B., Béné M. C, Minvielle S., Le Gouill S., Whole genome copy number analysis in search of new prognostic biomarkers in first line treatment of mantle cell lymphoma. A study by the LYSA group. Hematological Oncology., 2020, Online ahead of print. Réf. HAL: inserm-02874026

Le Calvez B., Le Bris Y., Herbreteau G., Jamet B., Bossard C., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Antier C., Theisen O., Kraeber-Bodéré F., Le Gouill S., Béné M.C., Moreau P., Touzeau C., RASmutation leading to acquired resistance to dabrafenib and trametinib therapy in a multiplemyeloma patient harboring BRAF mutation. European Journal of Haematology., 2020, Online ahead of print. Réf. HAL: inserm-02874002

Le Gouill S., Beldi-Ferchiou A., Alcantara M., Cacheux V., Safar V., Burroni B., Guidez S., Gastinne T., Canioni D., Thieblemont C., Maisonneuve H., Bodet-Milin C., Houot R., Oberic L., Bouabdallah K., Bescond C., Damaj G., Jaccard A., Daguindau N., Moreau A., Tilly H., Ribrag V., Delfau-Larue M.H., Hermine O., Macintyre E., Molecular response after obinutuzumab plus high-dose cytarabine induction for transplant-eligible patients with untreated mantle cell lymphoma (LyMa-101): a phase 2 trial of the LYSA group. Lancet Haematology., 2020, vol 7, n°11, e798-e807. Réf. HAL: hal-03012903

Le Gouill S., Morschhauser F., Chiron D., Bouabdallah K., Cartron G., Casasnovas O., Bodet-Milin C. M, Ragot S., Bossard C., Nadal N., Herbaux C., Tessoulin B., Tchernonog E., Rossi C., Mc Culloch R., Gastinne T., Callanan M., Rule S., Ibrutinib, Obinutuzumab And Venetoclax In Relapsed and Untreated Patients with Mantle-Cell Lymphoma, a phase I/II trial. Blood., 2020, Online ahead of print. Réf. HAL: inserm-03063717

Lohard S., Bourgeois N., Maillet L. A, Gautier F. P, Fétiveau A., Lasla H., Nguyen F., Vuillier C., Dumont A., Moreau-Aubry A., Frapin M., David L., Loussouarn D., Kerdraon O., Campone M., Jézéquel P., Juin P., Barillé-Nion S., STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment. Nature Communications., 2020, vol 11, n°1, 259 p. Réf. HAL: inserm-02448103

Michaud-Robert A.V., Zamagni E., Carlier T., Bailly C., Jamet B., Touzeau C., Moreau P., Kraeber-Bodere F., Nanni C., Bodet-Milin C., Glucose Metabolism Quantified by SUVmax on Baseline FDG-PET/CT Predicts Survival in Newly Diagnosed Multiple Myeloma Patients: Combined Harmonized Analysis of Two Prospective Phase III Trials. Cancers., 2020, vol 12, n°9, 2532 p. Réf. HAL: inserm-03497417

Seiller C., Maiga S., Touzeau C., Bellanger C., Kervoëlen C., Descamps G., Maillet L., Moreau P., Pellat-Deceunynck C., Gomez-Bougie P., Amiot M., Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/ BAK hetero-complexes. Cell Death and Disease., 2020, vol 11, 316 p. Réf. HAL: inserm-02563554

Sesques P., Bourcier J., Golfier C., Lebras L., Nicolas‐virelizier E., Hacini M., Perrin M.C., Voillat L., Bachy E., Traverse‐glehen A., Moreau A., Martin L., Ramla S., Casasnovas O., Le Gouill S., Salles G., Ghesquières H., Clinical characteristics and outcomes of relapsed follicular lymphoma after autologous stem cell transplantation in the rituximab era. Hematological Oncology., 2020, vol 38, n°2, 137-145 p. Réf. HAL: inserm-03496368

Sortais C., Lok A., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Touzeau C., Moreau A., Bossard C., Peterlin P., Garnier A., Guillaume T., Le Bourgeois A., Chevallier P., Moreau P., Leux C., Le Gouill S., Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life. Annals of Hematology., 2020, vol 99, n°7, 1595-1604 p. Réf. HAL: inserm-03498746

Tessoulin B., Bouabdallah K., Burroni B., Lamy T., Gressin R., Cartron G., Thieblemont C., Sarkozy C., Haioun C., Casasnovas O., Joubert C., Gyan E., Hermine O., Le Gouill S., Safety and efficacy of temsirolimus in combination with three different immuno-chemotherapy regimens in relapse and refractory mantle cell lymphoma, final results of the T phase IB trial of the LYSA. Annals of Hematology., 2020, vol 99, n°8, 1771-1778 p. Réf. HAL: hal-02890227

Tessoulin B., Le Gouill S., Approved and new indications of CART T-cells in Non-Hodgkin Lymphomas. Hématologie., 2020, vol 26, n°S5, 24-37 p. Réf. HAL: inserm-03495948

Touzeau C., Prise en charge du patient greffé et éligible à la greffe : traitements d’entretien et bénéficies associés. Hématologie., 2020, vol 26, 21-27 p. Réf. HAL: inserm-03498419

Vercellino L., Di Blasi R., Kanoun S., Tessoulin B., Rossi C., D’aveni-Piney M., Obéric L., Bodet-Milin C., Bories P., Olivier P., Lafon I., Berriolo-Riedinger A., Galli E., Bernard S., Rubio M.T., Bossard C., Meignin V., Merlet P., Feugier P., Le Gouill S., Ysebaert L., Casasnovas O., Meignan M., Chevret S., Thieblemont C., Predictive factors of early progression after CAR T-cell therapy in relapsed/refractory diffuse large B-cell lymphoma. Blood Advances., 2020, vol 4, n°22, 5607-5615 p. Réf. HAL: hal-03226567

Equipe 12 « Manipulation of Lymphocytes for Immunotherapy »

Béné M., De Carvalho-Bittencourt M., Eveillard M., Le Bris Y., Good IgA Bad IgG in SARS-CoV-2 Infection? Clinical Infectious Diseases., 2020, vol 71, n°15, 897-898 p. Réf. HAL: hal-02971254

Carapito R., Aouadi I., Pichot A., Spinnhirny P., Morlon A., Kotova I., Macquin C., Rolli V., Cesbron A., Gagne K., Oudshoorn M., Van Der Holt B., Labalette M., Spierings E., Picard C., Loiseau P., Tamouza R., Toubert A., Parissiadis A., Dubois V., Paillard C., Maumy-Bertrand M., Bertrand F., Von Dem Borne P. A., Kuball J. H. E., Michallet M., Lioure B., Peffault De Latour R., Blaise D., Cornelissen J.J., Yakoub Agha I., Claas F.H., Moreau P., Charron D., Mohty M., Morishima Y., Socié G., Bahram S., Compatibility at amino acid position 98 of MICB reduces the incidence of graft-versus host disease in conjunction with the CMV status. Bone Marrow Transplantation., 2020, vol 15, Online ahead of print. Réf. HAL: inserm-02545513

Debord C., Wuillème S., Eveillard M., Theisen O., Godon C., Le Bris Y., Béné M., Flow cytometry in the diagnosis of mature B‐cell lymphoproliferative disorders. International Journal of Laboratory Hematology., 2020, vol 42, n°S1, 113-120 p. Réf. HAL: inserm-03496870

Deleers M., Breiman A., Daubie V., Maggetto C., Barreau I., Besse T., Clémenceau B., Ruvoën-Clouet N., Fils J.F., Maillart E., Doyen V., Mahadeb B., Jani J., Der Linden P. Van, Cannie M., Hayef N., Corazza F., Le Pendu J., Kenz H. El, Covid-19 and blood groups: ABO antibody levels may also matter. International Journal of Infectious Diseases., 2020, S1201-9712(20)32549-2. Réf. HAL: inserm-03094253

Droillard C., Lemaitre E., Chatel M., Quéméner A., Briand F.X., Guitton J.S., Marchandeau S., Lependu J., Eterradossi N., Le Gall-Recule G., Genetic diversity and evolution of Hare Calicivirus (HaCV), a recentlyidentified lagovirus fromLepus europaeus. Infection, Genetics and Evolution., 2020, 104310 p. Réf. HAL: inserm-02533007

Dubreuil L., Maniangou B., Chevallier P., Quéméner A., Legrand N., Béné M. C, Willem C., David G., Alizadeh M., Makanga D. Roméo, Cesbron A., Gendzekhadze K., Gagne K., Retière C., Centromeric KIR AA Individuals Harbor Particular KIR Alleles Conferring Beneficial NK Cell Features with Implications in Haplo-Identical Hematopoietic Stem Cell Transplantation. Cancers., 2020, vol 12, n°12, 3595 p. Réf. HAL: inserm-03035170

Fiore P.F., Di Matteo S., Tumino N., Mariotti F.R., Pietra G., Ottonello S., Negrini S., Bottazzi B., Moretta L., Mortier E., Azzarone B., Interleukin-15 and cancer: some solved and many unsolved questions. Journal for Immunotherapy of Cancer., 2020,. Réf. HAL: inserm-03013809

Harly C., Bhandoola A., Switch hitter: Bcl11b in T cells and ILC2s. Journal of Experimental Medicine., 2020, vol 217, n°1, e20191739. Réf. HAL: inserm-02541576

Harly C., Kenney D., Wang Y., Ding Y., Zhao Y., Awasthi P., Bhandoola A., A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments. Frontiers in Immunology., 2020, vol 11, 470 p. Réf. HAL: inserm-02541580

Joalland N., Scotet E., Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells. Frontiers in Immunology., 2020, vol 11, 992 p. Réf. HAL: inserm-02908442

Kervarrec T., Tallegas M., Schrama D., Houben R., Ollier J., Clemenceau B., Vié H., Touzé A., Samimi M., Guyetant S., BerEP4 positivity in Merkel cell carcinoma: a potential diagnosis pitfall. Journal of the European Academy of Dermatology and Venereology., 2020, vol 34, n°11, e707-e709. Réf. HAL: inserm-02908448

Le Bris Y., Magrangeas F., Moreau A., Chiron D., Guérin-Charbonnel C., Theisen O., Pichon O., Canioni D., Burroni B., Maisonneuve H., Thieblemont C., Oberic L., Gyan E., Pellat-Deceunynck C., Hermine O., Delfau-Larue M.H., Tessoulin B., Béné M. C, Minvielle S., Le Gouill S., Whole genome copy number analysis in search of new prognostic biomarkers in first line treatment of mantle cell lymphoma. A study by the LYSA group. Hematological Oncology., 2020, Online ahead of print. Réf. HAL: inserm-02874026

Legrand N., David G., Rodallec A., Gaultier A., Salmon D., Cesbron A., Wittkop L., Raffi F., Gendzekhadze K., Retière C., Allavena C., Gagne K., European HIV-HCV co-infected individuals Short title: HLA-C and spontaneous clearance in HIV-HCV coinfection. Clinical and Experimental Immunology., 2020,. Réf. HAL: inserm-03063756

Makanga D.R., Da Rin De Lorenzo F., David G., Willem C., Dubreuil L., Legrand N., Guillaume T., Peterlin P., Lebourgeois A., Béné M.C., Garnier A., Chevallier P., Gendzekhadze K., Cesbron A., Gagne K., Clemenceau B., Retière C., Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia. Cancers., 2020, vol 12, n°7, 1927 p. Réf. HAL: inserm-02913794

Makanga D. Roméo, Guillaume T., Willem C., Legrand N., Gagne K., Cesbron A., Gendzekhadze K., Peterlin P., Garnier A., Le Bourgeois A., Béné M. C, Chevallier P., Retiere C., Posttransplant Cyclophosphamide and Antithymocyte Globulin versus Posttransplant Cyclophosphamide as Graft-versus-Host Disease Prophylaxis for Peripheral Blood Stem Cell Haploidentical Transplants: Comparison of T Cell and NK Effector Reconstitution. Journal of Immunology., 2020, vol 205, n°5, 1441 – 1448 p. Réf. HAL: inserm-03290602

Marotte L., Simon S., Vignard V., Dupré E., Gantier M., Cruard J., Alberge J.B., Hussong M., Deleine C., Heslan J.M., Shaffer J., Beauvais T., Gaschet J., Scotet E., Fradin D., Jarry A., Nguyen T., Labarrière N., Increased antitumor efficacy of PD-1- deficient melanoma-specific human lymphocytes. Journal for Immunotherapy of Cancer., 2020, vol 8, e000311. Réf. HAL: inserm-02481085

Mortier E., Ma A., Malynn B. A, Neurath M. F, Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer. Frontiers in Immunology., 2020,. Réf. HAL: inserm-02971041

Moulin C., Guillemin F., Rémen T., Bouclet F., Augé H., Quinquenel A., Dartigeas C., Morizot R., Lomazzi S., Busby H., Hergalant S., Tausch E., Tomowiak C., Leblond V., Thieblemont C., Cymbalista F., Laribi K., Bene M., Stilgenbauer S., Guieze R., Feugier P., Broséus J., Clinico-Biological, Molecular and Prognostic Features of Patients with Diffuse Large B-Cell Lymphoma-Variant of Richter Syndrome: A Multicenter Retrospective Study of the French Innovative Leukemia Organization. Blood., 2020, vol 136, n°Suppl 1, 3-5 p. Réf. HAL: hal-03054135

Nehme A., Dakik H., Picou F., Cheok M., Preudhomme C., Dombret H., Lambert J., Gyan E., Pigneux A., Récher C., Béné M., Gouilleux F., Zibara K., Herault O., Mazurier F., Horizontal meta-analysis identifies common deregulated genes across AML subgroups providing a robust prognostic signature. Blood Advances., 2020, vol 4, n°20, 5322-5335 p. Réf. HAL: hal-03003907

Perroteau J., Navet B., Devilder M.C., Hesnard L., Scotet E., Gapin L., Saulquin X., Gautreau-Rolland L., Contribution of the SYK Tyrosine kinase expression to human iNKT self-reactivity. European Journal of Immunology., 2020, Online ahead of print. Réf. HAL: inserm-02874033

Rabé M., Dumont S., Álvarez-Arenas A., Janati H., Belmonte-Beitia J., Calvo G. F, Thibault-Carpentier C., Séry Q., Chauvin C., Joalland N., Briand F., Blandin S., Scotet E., Pecqueur C., Clairambault J., Oliver L., Pérez-García V., Nadaradjane A. M, Cartron P.F., Gratas C., Vallette F., Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma. Cell Death and Disease., 2020,. Réf. HAL: hal-02429194

Rafia C., Harly C., Scotet E., Beyond CAR T cells: Engineered Vγ9Vδ2 T cells to fight solid tumors. Immunological Reviews., 2020, vol 298, n°1, 117-133 p. Réf. HAL: inserm-03496227

Renand A., Cervera-Marzal I., Gil L., Dong C., Garcia A., Kervagoret E., Aublé H., Habes S., Chevalier C., Vavasseur F., Clémenceau B., Cardon A., Judor J.P., Mosnier J.F., Tanné F., Laplaud D.A., Brouard S., Gournay J., Milpied P., Conchon S., Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis. Journal of Hepatology., 2020,. Réf. HAL: hal-02982205

Sortais C., Lok A., Tessoulin B., Gastinne T., Mahé B., Dubruille V., Blin N., Touzeau C., Moreau A., Bossard C., Peterlin P., Garnier A., Guillaume T., Le Bourgeois A., Chevallier P., Moreau P., Leux C., Le Gouill S., Progression of disease within 2 years (POD24) is a clinically relevant endpoint to identify high-risk follicular lymphoma patients in real life. Annals of Hematology., 2020, vol 99, n°7, 1595-1604 p. Réf. HAL: inserm-03498746

Vandamme C., Xicluna R., Hesnard L., Devaux M., Jaulin N., Guilbaud M., Le Duff J., Couzinié C., Moullier P., Saulquin X., Adjali O., Tetramer-Based Enrichment of Preexisting Anti-AAV8 CD8 + T Cells in Human Donors Allows the Detection of a T EMRA Subpopulation. Frontiers in Immunology., 2020, vol 10, 3110 p. Réf. HAL: inserm-02447186

Vourc’h M., David G., Gaborit B., Broquet A., Jacqueline C., Chaumette T., Caillon J., Roquilly A., Retiere C., Asehnoune K., Pseudomonas aeruginosa Infection Impairs NKG2D-Dependent NK Cell Cytotoxicity through Regulatory T-Cell Activation. Infection and Immunity., 2020, vol 88, n°12, e00363-20. Réf. HAL: inserm-03290540

Guillonneau C., Anegon I., Mortier E., Quéméner A., Mutated Interleukin-34 (IL-34) Polypeptides and Uses Thereof in Therapy Patent n°WO2020148338 (2020). Réf. HAL: inserm-02991886

Saulquin X., Human Monoclonal Antibodies Binding to HLA-A2 Patent n°PCT/EP2020/050649 (2020). Réf. HAL: inserm-02547885

Saulquin X., Methods and Kits for Generating and Selecting a Variant of a Binding Protein with Increased Binding Affinity and/or Specificity Patent n°PCT/EP2020/050646 (2020). Réf. HAL: inserm-02547893