Research Projects de recherche

T lymphocytes, which are a subtype of white blood cell, play a central role in cell-mediated immunity. They are distinguished from other lymphocytes, such as B cells and natural killer (NK) cells, by the expression of a T cell receptor (TCR) on the cell surface. Team 1 has been working for decades on the immunobiology of human T lymphocytes that express either αβ or γδ TCR. The team was made of three subgroups which addressed complementary issues dealing with the immunobiology of human T lymphocytes and their immunotherapeutic use against infections and cancers.

In line with recent observations made by the team and its unique expertise that was recently strengthened by additional members and clinicians, our joint objectives are to pursue from a fundamental standpoint the analysis of the specificity and function(s) of human T lymphocyte subsets (e.g., αβ/γδ T and NK cells) and the impact of selected interleukins, such as IL-15, in physiopathological contexts. From both preclinical & clinical standpoints, the research work focuses on:
(i) the ways to optimize immunotherapies targeting human lymphoid subsets (e.g., development of orthotopic in vivo models);
(ii) the analysis of alloreactive T lymphocyte responses elicited along allograft transplantation, in relation with both clinical status and allograft outcome in patients;
(iii) the design of novel in vitro tools for medium-throughput screening approaches of lymphoid cell-mediated reactivities induced by therapeutic antibodies;
(iv) the biology of IL-15 and its therapeutical applications.

Biologie et fonctions des lymphocytes T humains non conventionnels γδ
Responsable : Emmanuel Scotet

Sélection et réactivité des cellules iNKT humaines/Développement d’anticorps monoclonaux humains
Responsable : Xavier Saulquin

Sélection et modifications fonctionnelles des lymphocytes T pour l’immunothérapie
Responsable : Henri Vié

Biologie de l’ IL-15 et applications thérapeutiques
Responsable : Erwan Mortier

Optimisation de la reconstitution immunitaire après greffe de cellules souches hématopoïétiques humaines
Responsable : Christelle Retière

Staff

Emmanuel Scotet, DR INSERM

Henry Vie, DR INSERM
Erwan Mortier, DR CNRS
Christelle Harly, CR CNRS
Xavier Saulquin, PU
Laetitia Gautreau, MCU
Fabienne Konczak-Del Gatto, MCU
Christelle Retière, DR
Kathia. Gagne, CR
Sabine Sévère, CR
Marie-Claire Devilder, CR
Béatrice Clémenceau, CR
Patrice Chevallier, PU-PH
Marie-Claire Béné, PU-PH
Thierry Guillaume, PH

Agnès Quemener, IR
Mike Maillasson, IE
Delphine Coulais, IE
Nolwenn Legrand, TCH
Gaëlle David-Bosquaux, TCH
Catherine Willem, TCH
Jocelyn Ollier, IE
Aurélie Domène IE

Chirine Rafia, PhD Student
Audrey Grain, PhD Student
Enora Ferron, PhD Student
Jimmy Smadja, PhD Student

Main Publications

  • Emmanuel Scotet
  • Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
  • Institut de Recherche en Santé de l'Université de Nantes - 8 quai Moncousu - BP 70721 - 44007 Nantes cedex 1
  • 02 28 08 02 23
  • emmanuel.scotet@inserm.fr